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Nuclear Localization of α1A‐Adrenergic Receptors Is Required for Signaling in Cardiac Myocytes: An “Inside‐Out” α1‐AR Signaling Pathway

BACKGROUND: Recent studies indicate that α1‐adrenergic receptors (α1‐ARs) are cardioprotective by preventing cardiac myocyte death and augmenting contractility in heart failure. Although G‐protein‐coupled receptors are assumed to localize to and signal at the plasma membrane, we previously demonstra...

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Detalles Bibliográficos
Autores principales:	Wu, Steven C., Dahl, Erika F., Wright, Casey D., Cypher, Andrew L., Healy, Chastity L., O'Connell, Timothy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187477/ https://www.ncbi.nlm.nih.gov/pubmed/24772522 http://dx.doi.org/10.1161/JAHA.113.000145

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