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Glutathionylation Mediates Angiotensin II–Induced eNOS Uncoupling, Amplifying NADPH Oxidase‐Dependent Endothelial Dysfunction

BACKGROUND: Glutathionylation of endothelial nitric oxide synthase (eNOS) “uncouples” the enzyme, switching its function from nitric oxide (NO) to O(2)(•−) generation. We examined whether this reversible redox modification plays a role in angiotensin II (Ang II)‐induced endothelial dysfunction. METH...

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Detalles Bibliográficos
Autores principales:	Galougahi, Keyvan Karimi, Liu, Chia‐Chi, Gentile, Carmine, Kok, Cindy, Nunez, Andrea, Garcia, Alvaro, Fry, Natasha A. S., Davies, Michael J., Hawkins, Clare L., Rasmussen, Helge H., Figtree, Gemma A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187489/ https://www.ncbi.nlm.nih.gov/pubmed/24755153 http://dx.doi.org/10.1161/JAHA.113.000731

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