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Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study

BACKGROUND: Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of th...

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Autores principales: Schmiegelow, Michelle Dalgas, Andersson, Charlotte, Køber, Lars, Andersen, Søren Skøtt, Norgaard, Mette Lykke, Jensen, Thomas Bo, Gislason, Gunnar, Berger, Siv Mari, Torp‐Pedersen, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187494/
https://www.ncbi.nlm.nih.gov/pubmed/24721798
http://dx.doi.org/10.1161/JAHA.113.000672
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author Schmiegelow, Michelle Dalgas
Andersson, Charlotte
Køber, Lars
Andersen, Søren Skøtt
Norgaard, Mette Lykke
Jensen, Thomas Bo
Gislason, Gunnar
Berger, Siv Mari
Torp‐Pedersen, Christian
author_facet Schmiegelow, Michelle Dalgas
Andersson, Charlotte
Køber, Lars
Andersen, Søren Skøtt
Norgaard, Mette Lykke
Jensen, Thomas Bo
Gislason, Gunnar
Berger, Siv Mari
Torp‐Pedersen, Christian
author_sort Schmiegelow, Michelle Dalgas
collection PubMed
description BACKGROUND: Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. METHODS AND RESULTS: Women giving birth during the years 2004–2009, with no history of cardiovascular disease, renal insufficiency, pregnancy‐associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese‐I (BMI=30 to <35 kg/m(2)), obese‐II (BMI=35 to <40 kg/m(2)), and obese‐III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow‐up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade‐I, 7.17 (CI=6.10 to 8.48) for obese grade‐II, and 6.93 (CI=5.47 to 8.79) for obese grade‐III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). CONCLUSIONS: In this nationwide study of fertile, apparently healthy women, pre‐pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth.
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spelling pubmed-41874942014-11-03 Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study Schmiegelow, Michelle Dalgas Andersson, Charlotte Køber, Lars Andersen, Søren Skøtt Norgaard, Mette Lykke Jensen, Thomas Bo Gislason, Gunnar Berger, Siv Mari Torp‐Pedersen, Christian J Am Heart Assoc Original Research BACKGROUND: Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. METHODS AND RESULTS: Women giving birth during the years 2004–2009, with no history of cardiovascular disease, renal insufficiency, pregnancy‐associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese‐I (BMI=30 to <35 kg/m(2)), obese‐II (BMI=35 to <40 kg/m(2)), and obese‐III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow‐up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade‐I, 7.17 (CI=6.10 to 8.48) for obese grade‐II, and 6.93 (CI=5.47 to 8.79) for obese grade‐III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). CONCLUSIONS: In this nationwide study of fertile, apparently healthy women, pre‐pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth. Blackwell Publishing Ltd 2014-04-25 /pmc/articles/PMC4187494/ /pubmed/24721798 http://dx.doi.org/10.1161/JAHA.113.000672 Text en © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Schmiegelow, Michelle Dalgas
Andersson, Charlotte
Køber, Lars
Andersen, Søren Skøtt
Norgaard, Mette Lykke
Jensen, Thomas Bo
Gislason, Gunnar
Berger, Siv Mari
Torp‐Pedersen, Christian
Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study
title Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study
title_full Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study
title_fullStr Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study
title_full_unstemmed Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study
title_short Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study
title_sort associations between body mass index and development of metabolic disorders in fertile women—a nationwide cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187494/
https://www.ncbi.nlm.nih.gov/pubmed/24721798
http://dx.doi.org/10.1161/JAHA.113.000672
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