Mkk4 Is a Negative Regulator of the Transforming Growth Factor Beta 1 Signaling Associated With Atrial Remodeling and Arrhythmogenesis With Age

BACKGROUND: Atrial fibrillation (AF), often associated with structural, fibrotic change in cardiac tissues involving regulatory signaling mediators, becomes increasingly common with age. In the present study, we explored the role of mitogen‐activated protein kinase kinase 4 (Mkk4), a critical compon...

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Detalles Bibliográficos
Autores principales: Davies, Laura, Jin, Jiawei, Shen, Weijin, Tsui, Hoyee, Shi, Ying, Wang, Yanwen, Zhang, Yanmin, Hao, Guoliang, Wu, Jingjing, Chen, Si, Fraser, James A., Dong, Nianguo, Christoffels, Vincent, Ravens, Ursula, Huang, Christopher L.‐H., Zhang, Henggui, Cartwright, Elizabeth J., Wang, Xin, Lei, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187508/
https://www.ncbi.nlm.nih.gov/pubmed/24721794
http://dx.doi.org/10.1161/JAHA.113.000340

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