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Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate

The effect of diastolic dysfunction (DD) on the timing of left ventricular (LV) diastolic longitudinal and circumferential expansion and their load dependence is not known. This study evaluated the timing of the peak early diastolic LV inflow velocity (E), mitral annular velocity (e′), and longitudi...

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Autores principales: Iwano, Hiroyuki, Pu, Min, Upadhya, Bharathi, Meyers, Brett, Vlachos, Pavlos, Little, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187544/
https://www.ncbi.nlm.nih.gov/pubmed/25035279
http://dx.doi.org/10.14814/phy2.12082
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author Iwano, Hiroyuki
Pu, Min
Upadhya, Bharathi
Meyers, Brett
Vlachos, Pavlos
Little, William C.
author_facet Iwano, Hiroyuki
Pu, Min
Upadhya, Bharathi
Meyers, Brett
Vlachos, Pavlos
Little, William C.
author_sort Iwano, Hiroyuki
collection PubMed
description The effect of diastolic dysfunction (DD) on the timing of left ventricular (LV) diastolic longitudinal and circumferential expansion and their load dependence is not known. This study evaluated the timing of the peak early diastolic LV inflow velocity (E), mitral annular velocity (e′), and longitudinal and circumferential global strain rates (SR(E)) in 161 patients in sinus rhythm. The intraventricular pressure difference (IVPD) from the left atrium to the LV apex was obtained using color M‐mode Doppler data to integrate the Euler equation. The diastolic function was graded according to the guidelines. In normals (N = 57), E, e′, longitudinal SR(E), and circumferential SR(E) occurred nearly simultaneously during the IVPD. With DD (N = 104), e′ and longitudinal SR(E) were delayed occurring after the IVPD (e′: 18 ± 23 msec, longitudinal SR(E): 13 ± 21 msec from the IVPD), whereas circumferential SR(E) (−8 ± 28 msec) and E (−2 ± 13 msec) were not delayed. The normal dependence of e′ and longitudinal SR(E) on IVPD was reduced in DD; while the relation of circumferential SR(E) and E to IVPD were unchanged in DD. Thus, normally, the LV expands symmetrically during early diastole and both longitudinal and circumferential expansions are related to the IVPD. With DD, early diastolic longitudinal LV expansion is delayed, occurring after the IVPD and LV filling, resulting in their relative independence from the IVPD. In contrast, with DD, circumferential SR(E) and mitral inflow are not delayed and their normal relation to the IVPD is unchanged.
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spelling pubmed-41875442014-11-12 Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate Iwano, Hiroyuki Pu, Min Upadhya, Bharathi Meyers, Brett Vlachos, Pavlos Little, William C. Physiol Rep Original Research The effect of diastolic dysfunction (DD) on the timing of left ventricular (LV) diastolic longitudinal and circumferential expansion and their load dependence is not known. This study evaluated the timing of the peak early diastolic LV inflow velocity (E), mitral annular velocity (e′), and longitudinal and circumferential global strain rates (SR(E)) in 161 patients in sinus rhythm. The intraventricular pressure difference (IVPD) from the left atrium to the LV apex was obtained using color M‐mode Doppler data to integrate the Euler equation. The diastolic function was graded according to the guidelines. In normals (N = 57), E, e′, longitudinal SR(E), and circumferential SR(E) occurred nearly simultaneously during the IVPD. With DD (N = 104), e′ and longitudinal SR(E) were delayed occurring after the IVPD (e′: 18 ± 23 msec, longitudinal SR(E): 13 ± 21 msec from the IVPD), whereas circumferential SR(E) (−8 ± 28 msec) and E (−2 ± 13 msec) were not delayed. The normal dependence of e′ and longitudinal SR(E) on IVPD was reduced in DD; while the relation of circumferential SR(E) and E to IVPD were unchanged in DD. Thus, normally, the LV expands symmetrically during early diastole and both longitudinal and circumferential expansions are related to the IVPD. With DD, early diastolic longitudinal LV expansion is delayed, occurring after the IVPD and LV filling, resulting in their relative independence from the IVPD. In contrast, with DD, circumferential SR(E) and mitral inflow are not delayed and their normal relation to the IVPD is unchanged. Wiley Periodicals, Inc. 2014-07-17 /pmc/articles/PMC4187544/ /pubmed/25035279 http://dx.doi.org/10.14814/phy2.12082 Text en © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Iwano, Hiroyuki
Pu, Min
Upadhya, Bharathi
Meyers, Brett
Vlachos, Pavlos
Little, William C.
Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate
title Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate
title_full Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate
title_fullStr Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate
title_full_unstemmed Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate
title_short Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate
title_sort delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187544/
https://www.ncbi.nlm.nih.gov/pubmed/25035279
http://dx.doi.org/10.14814/phy2.12082
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