The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas

Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to incre...

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Autores principales: Boender, Arjen J., van Gestel, Margriet A., Garner, Keith M., Luijendijk, Mieneke C. M., Adan, Roger A. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187548/
https://www.ncbi.nlm.nih.gov/pubmed/25077509
http://dx.doi.org/10.14814/phy2.12083
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author Boender, Arjen J.
van Gestel, Margriet A.
Garner, Keith M.
Luijendijk, Mieneke C. M.
Adan, Roger A. H.
author_facet Boender, Arjen J.
van Gestel, Margriet A.
Garner, Keith M.
Luijendijk, Mieneke C. M.
Adan, Roger A. H.
author_sort Boender, Arjen J.
collection PubMed
description Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to increases in body weight, presumably via increased food intake. Moreover, we observed that both increased and decreased levels of Negr1 lead to reduced locomotor activity and body temperature. In sum, our results provide further support for a role of hypothalamic expressed Negr1 in the regulation of energy balance.
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spelling pubmed-41875482014-11-12 The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas Boender, Arjen J. van Gestel, Margriet A. Garner, Keith M. Luijendijk, Mieneke C. M. Adan, Roger A. H. Physiol Rep Original Research Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to increases in body weight, presumably via increased food intake. Moreover, we observed that both increased and decreased levels of Negr1 lead to reduced locomotor activity and body temperature. In sum, our results provide further support for a role of hypothalamic expressed Negr1 in the regulation of energy balance. Wiley Periodicals, Inc. 2014-07-22 /pmc/articles/PMC4187548/ /pubmed/25077509 http://dx.doi.org/10.14814/phy2.12083 Text en © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Boender, Arjen J.
van Gestel, Margriet A.
Garner, Keith M.
Luijendijk, Mieneke C. M.
Adan, Roger A. H.
The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas
title The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas
title_full The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas
title_fullStr The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas
title_full_unstemmed The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas
title_short The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas
title_sort obesity‐associated gene negr1 regulates aspects of energy balance in rat hypothalamic areas
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187548/
https://www.ncbi.nlm.nih.gov/pubmed/25077509
http://dx.doi.org/10.14814/phy2.12083
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