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Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune-based approaches have shown great p...
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Format: | Online Article Text |
Language: | English |
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Frontiers Media S.A.
2014
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187613/ https://www.ncbi.nlm.nih.gov/pubmed/25340042 http://dx.doi.org/10.3389/fonc.2014.00275 |
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author | Schuessler, Andrea Walker, David G. Khanna, Rajiv |
author_facet | Schuessler, Andrea Walker, David G. Khanna, Rajiv |
author_sort | Schuessler, Andrea |
collection | PubMed |
description | Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune-based approaches have shown great promise. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. Here, we review the rationale for using CMV as a therapeutic target and discuss the first clinical evidence for safety and efficacy of CMV-specific cellular immunotherapy for GBM. |
format | Online Article Text |
id | pubmed-4187613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41876132014-10-22 Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme Schuessler, Andrea Walker, David G. Khanna, Rajiv Front Oncol Oncology Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune-based approaches have shown great promise. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. Here, we review the rationale for using CMV as a therapeutic target and discuss the first clinical evidence for safety and efficacy of CMV-specific cellular immunotherapy for GBM. Frontiers Media S.A. 2014-10-07 /pmc/articles/PMC4187613/ /pubmed/25340042 http://dx.doi.org/10.3389/fonc.2014.00275 Text en Copyright © 2014 Schuessler, Walker and Khanna. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Schuessler, Andrea Walker, David G. Khanna, Rajiv Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme |
title | Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme |
title_full | Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme |
title_fullStr | Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme |
title_full_unstemmed | Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme |
title_short | Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme |
title_sort | cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187613/ https://www.ncbi.nlm.nih.gov/pubmed/25340042 http://dx.doi.org/10.3389/fonc.2014.00275 |
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