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Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme

Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune-based approaches have shown great p...

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Main Authors: Schuessler, Andrea, Walker, David G., Khanna, Rajiv
Format: Online Article Text
Language:English
Published: Frontiers Media S.A. 2014
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187613/
https://www.ncbi.nlm.nih.gov/pubmed/25340042
http://dx.doi.org/10.3389/fonc.2014.00275
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author Schuessler, Andrea
Walker, David G.
Khanna, Rajiv
author_facet Schuessler, Andrea
Walker, David G.
Khanna, Rajiv
author_sort Schuessler, Andrea
collection PubMed
description Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune-based approaches have shown great promise. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. Here, we review the rationale for using CMV as a therapeutic target and discuss the first clinical evidence for safety and efficacy of CMV-specific cellular immunotherapy for GBM.
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spelling pubmed-41876132014-10-22 Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme Schuessler, Andrea Walker, David G. Khanna, Rajiv Front Oncol Oncology Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune-based approaches have shown great promise. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. Here, we review the rationale for using CMV as a therapeutic target and discuss the first clinical evidence for safety and efficacy of CMV-specific cellular immunotherapy for GBM. Frontiers Media S.A. 2014-10-07 /pmc/articles/PMC4187613/ /pubmed/25340042 http://dx.doi.org/10.3389/fonc.2014.00275 Text en Copyright © 2014 Schuessler, Walker and Khanna. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Schuessler, Andrea
Walker, David G.
Khanna, Rajiv
Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
title Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
title_full Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
title_fullStr Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
title_full_unstemmed Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
title_short Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
title_sort cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187613/
https://www.ncbi.nlm.nih.gov/pubmed/25340042
http://dx.doi.org/10.3389/fonc.2014.00275
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