Cargando…

CLC channel function and dysfunction in health and disease

CLC channels and transporters are expressed in most tissues and fulfill diverse functions. There are four human CLC channels, ClC-1, ClC-2, ClC-Ka, and ClC-Kb, and five CLC transporters, ClC-3 through −7. Some of the CLC channels additionally associate with accessory subunits. Whereas barttin is man...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stölting, Gabriel, Fischer, Martin, Fahlke, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188032/ https://www.ncbi.nlm.nih.gov/pubmed/25339907 http://dx.doi.org/10.3389/fphys.2014.00378

Ejemplares similares

Physiology and Pathophysiology of ClC-K/barttin Channels
por: Fahlke, Christoph, et al.
Publicado: (2010)

Reduced Membrane Insertion of CLC-K by V33L Barttin Results in Loss of Hearing, but Leaves Kidney Function Intact
por: Tan, Hua, et al.
Publicado: (2017)

Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl(-)/H(+) Antiporter ClC-5
por: Wojciechowski, Daniel, et al.
Publicado: (2018)

Regulation of ClC-2 gating by intracellular ATP
por: Stölting, Gabriel, et al.
Publicado: (2013)

Channel-like slippage modes in the human anion/proton exchanger ClC-4
por: Alekov, Alexi K., et al.
Publicado: (2009)

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
por: Schewe, Julia, et al.
Publicado: (2019)

Author Correction: Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
por: Schewe, Julia, et al.
Publicado: (2022)

Impaired Wheel Running Exercise in CLC-1 Chloride Channel-Deficient Myotonic Mice
por: van Lunteren, Erik, et al.
Publicado: (2011)

The CLC-5 2Cl(−)/H(+) exchange transporter in endosomal function and Dent's disease
por: Lippiat, Jonathan D., et al.
Publicado: (2012)

Apo state pore opening as functional basis of increased EAAT anion channel activity in episodic ataxia 6
por: Suslova, Mariia, et al.
Publicado: (2023)

Editorial: Combining computational and experimental approaches to characterize ion channels and transporters
por: Fahlke, Christoph, et al.
Publicado: (2023)

Metabolic energy sensing by mammalian CLC anion/proton exchangers
por: Grieschat, Matthias, et al.
Publicado: (2020)

ClC chloride channels
por: Mindell, Joe, et al.
Publicado: (2001)

Membrane Physiology and Biophysics—What Remains to Be Done?
por: Fahlke, Christoph
Publicado: (2020)

Membrane physiology and biophysics—Another milestone
por: Fahlke, Christoph
Publicado: (2022)

Mutations associated with Dent's disease affect gating and voltage dependence of the human anion/proton exchanger ClC-5
por: Alekov, Alexi K.
Publicado: (2015)

GlialCAM, a CLC-2 Cl(-) Channel Subunit, Activates the Slow Gate of CLC Chloride Channels
por: Jeworutzki, Elena, et al.
Publicado: (2014)

BK(Ca) channel dysfunction in neurological diseases
por: N'Gouemo, Prosper
Publicado: (2014)

Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases
por: Wang, Sijian, et al.
Publicado: (2022)

Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons
por: Guzman, Raul E., et al.
Publicado: (2014)

Presenilin adopts the ClC channel fold
por: Theobald, Douglas L.
Publicado: (2016)

ClC Channels: Reading Eukaryotic Function through Prokaryotic Spectacles
por: Miller, Christopher
Publicado: (2003)

Cysteine Modification of a Putative Pore Residue in Clc-0: Implication for the Pore Stoichiometry of Clc Chloride Channels
por: Lin, Chia-Wei, et al.
Publicado: (2000)

ClC1 chloride channel in myotonic dystrophy type 2 and ClC1 splicing in vitro
por: URSU, SIMONA-FELICIA, et al.
Publicado: (2012)

Structure of the human ClC-1 chloride channel
por: Wang, Kaituo, et al.
Publicado: (2019)

Determination of oligomeric states of proteins via dual-color colocalization with single molecule localization microscopy
por: Tan, Hua Leonhard, et al.
Publicado: (2022)

Dual-color Colocalization in Single-molecule Localization Microscopy to Determine the Oligomeric State of Proteins in the Plasma Membrane
por: Tan, Hua Leonhard, et al.
Publicado: (2023)

Editorial: Ion channels in health and disease
por: Al-Sabi, Ahmed, et al.
Publicado: (2022)

Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels
por: Moraes, Raiana dos Anjos, et al.
Publicado: (2021)

Physiology and Pathophysiology of CLC-1: Mechanisms of a Chloride Channel Disease, Myotonia
por: Tang, Chih-Yung, et al.
Publicado: (2011)

ClC-3 chloride channel in hippocampal neuronal apoptosis
por: Xu, Lijuan, et al.
Publicado: (2013)

Modulation of the slow/common gating of CLC channels by intracellular cadmium
por: Yu, Yawei, et al.
Publicado: (2015)

Structure of the CLC-1 chloride channel from Homo sapiens
por: Park, Eunyong, et al.
Publicado: (2018)

Electro-steric opening of the clc-2 chloride channel gate
por: De Jesús-Pérez, José J., et al.
Publicado: (2021)

Backbone amides are determinants of Cl(−) selectivity in CLC ion channels
por: Leisle, Lilia, et al.
Publicado: (2022)

Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle
por: Lueck, John D., et al.
Publicado: (2010)

ClC Channels and Transporters: Structure, Physiological Functions, and Implications in Human Chloride Channelopathies
por: Poroca, Diogo R., et al.
Publicado: (2017)

ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway
por: Sierra-Marquez, Juan, et al.
Publicado: (2022)

Neurodegeneration Upon Dysfunction of Endosomal/Lysosomal CLC Chloride Transporters
por: Bose, Shroddha, et al.
Publicado: (2021)

Vesicular CLC chloride/proton exchangers in health and diseases
por: Picollo, Alessandra
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pv5l1jpklc2ah9vdm7s1ui11an