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Structure‐energy‐based predictions and network modelling of RASopathy and cancer missense mutations
The Ras/MAPK syndromes (‘RASopathies’) are a class of developmental disorders caused by germline mutations in 15 genes encoding proteins of the Ras/mitogen‐activated protein kinase (MAPK) pathway frequently involved in cancer. Little is known about the molecular mechanisms underlying the differences...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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European Molecular Biology Organization
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188041/ https://www.ncbi.nlm.nih.gov/pubmed/24803665 http://dx.doi.org/10.1002/msb.20145092 |