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Low serum level of high‐sensitivity C‐reactive protein in a Japanese patient with maturity‐onset diabetes of the young type 3 (MODY3)
High‐sensitivity C‐reactive protein (hs‐CRP) levels in European populations are lower in patients with maturity‐onset diabetes of the young type 3 (MODY3) than in those with type 2 diabetes. hs‐CRP levels have been suggested to be useful for discriminating MODY3 from type 2 diabetes. As hs‐CRP level...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley-Blackwell
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188108/ https://www.ncbi.nlm.nih.gov/pubmed/25411618 http://dx.doi.org/10.1111/jdi.12237 |
Sumario: | High‐sensitivity C‐reactive protein (hs‐CRP) levels in European populations are lower in patients with maturity‐onset diabetes of the young type 3 (MODY3) than in those with type 2 diabetes. hs‐CRP levels have been suggested to be useful for discriminating MODY3 from type 2 diabetes. As hs‐CRP levels are influenced by various factors including race and body mass index, it is worthwhile to examine whether hs‐CRP can serve as a biomarker for MODY3 in Japanese. Here we describe the case of a Japanese MODY3 patient with a nonsense mutation in the HNF1A gene. Two measurements showed consistently lower hs‐CRP levels (<0.05 and 0.09 mg/L) than in Japanese patients with type 1 and type 2 diabetes. Hepatic expression of Crp messenger ribonucleic acid was significantly decreased in Hnf1a knockout mice. The hs‐CRP level might be a useful biomarker for MODY3 in both Japanese and European populations. |
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