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Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus

AIMS/INTRODUCTION: Brachial artery flow‐mediated dilation (FMD) is a method of evaluating the function of vascular endothelial cells and is utilized for early diagnosis of atherosclerotic diseases. Only a few studies evaluated the risks for major vascular complications in youth with type 1 and 2 dia...

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Autores principales: Ohsugi, Koji, Sugawara, Hidenori, Ebina, Kanako, Shiga, Kentaro, Kikuchi, Nobuyuki, Mori, Masaaki, Yokota, Shumpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Blackwell 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188121/
https://www.ncbi.nlm.nih.gov/pubmed/25411631
http://dx.doi.org/10.1111/jdi.12191
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author Ohsugi, Koji
Sugawara, Hidenori
Ebina, Kanako
Shiga, Kentaro
Kikuchi, Nobuyuki
Mori, Masaaki
Yokota, Shumpei
author_facet Ohsugi, Koji
Sugawara, Hidenori
Ebina, Kanako
Shiga, Kentaro
Kikuchi, Nobuyuki
Mori, Masaaki
Yokota, Shumpei
author_sort Ohsugi, Koji
collection PubMed
description AIMS/INTRODUCTION: Brachial artery flow‐mediated dilation (FMD) is a method of evaluating the function of vascular endothelial cells and is utilized for early diagnosis of atherosclerotic diseases. Only a few studies evaluated the risks for major vascular complications in youth with type 1 and 2 diabetes mellitus from the aspect of the early development of atherosclerosis. We studied whether there is a difference in vascular endothelial cell function between youth with type 1 and 2 diabetes mellitus. MATERIALS AND METHODS: We assessed %FMD of 24 patients with type 1 diabetes mellitus and 27 patients with type 2 diabetes mellitus aged 12–20 years along with glycated hemoglobin, lipid metabolism markers such as triglycerides, and inflammatory biomarkers such as total adiponectin levels in adolescent patients with type 1 or 2 diabetes mellitus. The significance of the difference in each factor between the type 1 and type 2 diabetes groups was assessed using Student's t‐test. RESULTS: The %FMD was significantly lower in patients with type 2 diabetes. The body mass index and blood pressure were significantly higher, and total and high‐molecular‐weight adiponectin levels were significantly lower in patients with type 2 diabetes. %FMD significantly correlated with systolic blood pressure. CONCLUSIONS: The results suggest that youth with type 2 diabetes have more advanced damage of the vascular endothelium and therefore are at higher risk for major vascular complications. Therefore, monitoring the progression of atherosclerosis would also be beneficial in youth with diabetes mellitus, and measurement of FMD could be further warranted.
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spelling pubmed-41881212014-11-19 Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus Ohsugi, Koji Sugawara, Hidenori Ebina, Kanako Shiga, Kentaro Kikuchi, Nobuyuki Mori, Masaaki Yokota, Shumpei J Diabetes Investig Articles AIMS/INTRODUCTION: Brachial artery flow‐mediated dilation (FMD) is a method of evaluating the function of vascular endothelial cells and is utilized for early diagnosis of atherosclerotic diseases. Only a few studies evaluated the risks for major vascular complications in youth with type 1 and 2 diabetes mellitus from the aspect of the early development of atherosclerosis. We studied whether there is a difference in vascular endothelial cell function between youth with type 1 and 2 diabetes mellitus. MATERIALS AND METHODS: We assessed %FMD of 24 patients with type 1 diabetes mellitus and 27 patients with type 2 diabetes mellitus aged 12–20 years along with glycated hemoglobin, lipid metabolism markers such as triglycerides, and inflammatory biomarkers such as total adiponectin levels in adolescent patients with type 1 or 2 diabetes mellitus. The significance of the difference in each factor between the type 1 and type 2 diabetes groups was assessed using Student's t‐test. RESULTS: The %FMD was significantly lower in patients with type 2 diabetes. The body mass index and blood pressure were significantly higher, and total and high‐molecular‐weight adiponectin levels were significantly lower in patients with type 2 diabetes. %FMD significantly correlated with systolic blood pressure. CONCLUSIONS: The results suggest that youth with type 2 diabetes have more advanced damage of the vascular endothelium and therefore are at higher risk for major vascular complications. Therefore, monitoring the progression of atherosclerosis would also be beneficial in youth with diabetes mellitus, and measurement of FMD could be further warranted. Wiley-Blackwell 2014-02-26 2014-09 /pmc/articles/PMC4188121/ /pubmed/25411631 http://dx.doi.org/10.1111/jdi.12191 Text en © 2014 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Ohsugi, Koji
Sugawara, Hidenori
Ebina, Kanako
Shiga, Kentaro
Kikuchi, Nobuyuki
Mori, Masaaki
Yokota, Shumpei
Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus
title Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus
title_full Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus
title_fullStr Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus
title_full_unstemmed Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus
title_short Comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus
title_sort comparison of brachial artery flow‐mediated dilation in youth with type 1 and type 2 diabetes mellitus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188121/
https://www.ncbi.nlm.nih.gov/pubmed/25411631
http://dx.doi.org/10.1111/jdi.12191
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