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Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy
Aging sarcopenia and muscular dystrophy (MD) are two conditions characterized by lower skeletal muscle quantity, lower muscle strength, and lower physical performance. Aging is associated with a peculiar alteration in body composition called “sarcopenic obesity” characterized by a decrease in lean b...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188124/ https://www.ncbi.nlm.nih.gov/pubmed/25339901 http://dx.doi.org/10.3389/fnagi.2014.00274 |
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author | Merlini, Luciano Vagheggini, Alessandro Cocchi, Daniela |
author_facet | Merlini, Luciano Vagheggini, Alessandro Cocchi, Daniela |
author_sort | Merlini, Luciano |
collection | PubMed |
description | Aging sarcopenia and muscular dystrophy (MD) are two conditions characterized by lower skeletal muscle quantity, lower muscle strength, and lower physical performance. Aging is associated with a peculiar alteration in body composition called “sarcopenic obesity” characterized by a decrease in lean body mass and increase in fat mass. To evaluate the presence of sarcopenia and obesity in a cohort of adult patients with MD, we have used the measurement techniques considered golden standard for sarcopenia that is for muscle mass dual-energy X-ray absorptiometry (DXA), for muscle strength hand-held dynamometry (HHD), and for physical performance gait speed. The study involved 14 adult patients with different types of MD. We were able to demonstrate that all patients were sarcopenic obese. We showed, in fact, that all were sarcopenic based on appendicular lean, fat and bone free, mass index (ALMI). In addition, all resulted obese according to the percentage of body fat determined by DXA in contrast to their body mass index ranging from underweight to obese. Skeletal muscle mass determined by DXA was markedly reduced in all patients and correlated with residual muscle strength determined by HHD, and physical performances determined by gait speed and respiratory function. Finally, we showed that ALMI was the best linear explicator of muscle strength and physical function. Altogether, our study suggests the relevance of a proper evaluation of body composition in MD and we propose to use, both in research and practice, the measurement techniques that has already been demonstrated effective in aging sarcopenia. |
format | Online Article Text |
id | pubmed-4188124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41881242014-10-22 Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy Merlini, Luciano Vagheggini, Alessandro Cocchi, Daniela Front Aging Neurosci Neuroscience Aging sarcopenia and muscular dystrophy (MD) are two conditions characterized by lower skeletal muscle quantity, lower muscle strength, and lower physical performance. Aging is associated with a peculiar alteration in body composition called “sarcopenic obesity” characterized by a decrease in lean body mass and increase in fat mass. To evaluate the presence of sarcopenia and obesity in a cohort of adult patients with MD, we have used the measurement techniques considered golden standard for sarcopenia that is for muscle mass dual-energy X-ray absorptiometry (DXA), for muscle strength hand-held dynamometry (HHD), and for physical performance gait speed. The study involved 14 adult patients with different types of MD. We were able to demonstrate that all patients were sarcopenic obese. We showed, in fact, that all were sarcopenic based on appendicular lean, fat and bone free, mass index (ALMI). In addition, all resulted obese according to the percentage of body fat determined by DXA in contrast to their body mass index ranging from underweight to obese. Skeletal muscle mass determined by DXA was markedly reduced in all patients and correlated with residual muscle strength determined by HHD, and physical performances determined by gait speed and respiratory function. Finally, we showed that ALMI was the best linear explicator of muscle strength and physical function. Altogether, our study suggests the relevance of a proper evaluation of body composition in MD and we propose to use, both in research and practice, the measurement techniques that has already been demonstrated effective in aging sarcopenia. Frontiers Media S.A. 2014-10-07 /pmc/articles/PMC4188124/ /pubmed/25339901 http://dx.doi.org/10.3389/fnagi.2014.00274 Text en Copyright © 2014 Merlini, Vagheggini and Cocchi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Merlini, Luciano Vagheggini, Alessandro Cocchi, Daniela Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy |
title | Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy |
title_full | Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy |
title_fullStr | Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy |
title_full_unstemmed | Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy |
title_short | Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy |
title_sort | sarcopenia and sarcopenic obesity in patients with muscular dystrophy |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188124/ https://www.ncbi.nlm.nih.gov/pubmed/25339901 http://dx.doi.org/10.3389/fnagi.2014.00274 |
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