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Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy

Aging sarcopenia and muscular dystrophy (MD) are two conditions characterized by lower skeletal muscle quantity, lower muscle strength, and lower physical performance. Aging is associated with a peculiar alteration in body composition called “sarcopenic obesity” characterized by a decrease in lean b...

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Autores principales: Merlini, Luciano, Vagheggini, Alessandro, Cocchi, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188124/
https://www.ncbi.nlm.nih.gov/pubmed/25339901
http://dx.doi.org/10.3389/fnagi.2014.00274
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author Merlini, Luciano
Vagheggini, Alessandro
Cocchi, Daniela
author_facet Merlini, Luciano
Vagheggini, Alessandro
Cocchi, Daniela
author_sort Merlini, Luciano
collection PubMed
description Aging sarcopenia and muscular dystrophy (MD) are two conditions characterized by lower skeletal muscle quantity, lower muscle strength, and lower physical performance. Aging is associated with a peculiar alteration in body composition called “sarcopenic obesity” characterized by a decrease in lean body mass and increase in fat mass. To evaluate the presence of sarcopenia and obesity in a cohort of adult patients with MD, we have used the measurement techniques considered golden standard for sarcopenia that is for muscle mass dual-energy X-ray absorptiometry (DXA), for muscle strength hand-held dynamometry (HHD), and for physical performance gait speed. The study involved 14 adult patients with different types of MD. We were able to demonstrate that all patients were sarcopenic obese. We showed, in fact, that all were sarcopenic based on appendicular lean, fat and bone free, mass index (ALMI). In addition, all resulted obese according to the percentage of body fat determined by DXA in contrast to their body mass index ranging from underweight to obese. Skeletal muscle mass determined by DXA was markedly reduced in all patients and correlated with residual muscle strength determined by HHD, and physical performances determined by gait speed and respiratory function. Finally, we showed that ALMI was the best linear explicator of muscle strength and physical function. Altogether, our study suggests the relevance of a proper evaluation of body composition in MD and we propose to use, both in research and practice, the measurement techniques that has already been demonstrated effective in aging sarcopenia.
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spelling pubmed-41881242014-10-22 Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy Merlini, Luciano Vagheggini, Alessandro Cocchi, Daniela Front Aging Neurosci Neuroscience Aging sarcopenia and muscular dystrophy (MD) are two conditions characterized by lower skeletal muscle quantity, lower muscle strength, and lower physical performance. Aging is associated with a peculiar alteration in body composition called “sarcopenic obesity” characterized by a decrease in lean body mass and increase in fat mass. To evaluate the presence of sarcopenia and obesity in a cohort of adult patients with MD, we have used the measurement techniques considered golden standard for sarcopenia that is for muscle mass dual-energy X-ray absorptiometry (DXA), for muscle strength hand-held dynamometry (HHD), and for physical performance gait speed. The study involved 14 adult patients with different types of MD. We were able to demonstrate that all patients were sarcopenic obese. We showed, in fact, that all were sarcopenic based on appendicular lean, fat and bone free, mass index (ALMI). In addition, all resulted obese according to the percentage of body fat determined by DXA in contrast to their body mass index ranging from underweight to obese. Skeletal muscle mass determined by DXA was markedly reduced in all patients and correlated with residual muscle strength determined by HHD, and physical performances determined by gait speed and respiratory function. Finally, we showed that ALMI was the best linear explicator of muscle strength and physical function. Altogether, our study suggests the relevance of a proper evaluation of body composition in MD and we propose to use, both in research and practice, the measurement techniques that has already been demonstrated effective in aging sarcopenia. Frontiers Media S.A. 2014-10-07 /pmc/articles/PMC4188124/ /pubmed/25339901 http://dx.doi.org/10.3389/fnagi.2014.00274 Text en Copyright © 2014 Merlini, Vagheggini and Cocchi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Merlini, Luciano
Vagheggini, Alessandro
Cocchi, Daniela
Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy
title Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy
title_full Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy
title_fullStr Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy
title_full_unstemmed Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy
title_short Sarcopenia and Sarcopenic Obesity in Patients with Muscular Dystrophy
title_sort sarcopenia and sarcopenic obesity in patients with muscular dystrophy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188124/
https://www.ncbi.nlm.nih.gov/pubmed/25339901
http://dx.doi.org/10.3389/fnagi.2014.00274
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