Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2 Gene is Not Associated with Stroke Risk in Han Population of Hunan China

BACKGROUND: It is still unclear which genetic factors have a role in stroke. Studies have found that Ala54Thr of Fatty Acid-Binding Protein 2 (FABP2) was associated with stroke risk. This study aimed to determine whether polymorphism Ala54Thr of FABP2 is associated with stroke risk in the Hunan Han population of China. MATERIAL/METHODS: A total of 206 cerebral infarction (CI) patients, 185 cerebral hemorrhage (CH) patients, and 172 controls were enrolled in this study. Ala54Thr genotyping was done by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). RESULTS: No significant difference was observed in genotypic distribution of FABP2 Ala54Thr between the stroke group (CI subgroup, CH subgroup included) and control group. In the stroke group, plasma triglycerides (TG) levels of subjects who carried Ala/Thr, Thr/Thr were significantly higher than those carrying Ala/Ala. In the control group, blood lipids were not significantly different among 3 genotypes of Ala54Thr. There was no significant difference in blood pressure and fasting blood sugar between the stroke group and controls. CONCLUSIONS: Our study showed that Ala54Thr of FABP2 may be not associated with stroke risk but may be associated with plasma TG level of stroke patients from a Hunan Han population of China.