The Homology Model of PMP22 Suggests Mutations Resulting in Peripheral Neuropathy Disrupt Transmembrane Helix Packing

[Image: see text] Peripheral myelin protein 22 (PMP22) is a tetraspan membrane protein strongly expressed in myelinating Schwann cells of the peripheral nervous system. Myriad missense mutations in PMP22 result in varying degrees of peripheral neuropathy. We used Rosetta 3.5 to generate a homology m...

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Detalles Bibliográficos
Autores principales: Mittendorf, Kathleen F., Kroncke, Brett M., Meiler, Jens, Sanders, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188248/
https://www.ncbi.nlm.nih.gov/pubmed/25243937
http://dx.doi.org/10.1021/bi500809t

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