21-Benzylidene Digoxin: A Proapoptotic Cardenolide of Cancer Cells That Up-Regulates Na,K-ATPase and Epithelial Tight Junctions

Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also be a hormone that modulates epithelial cell adhesion. Cardiotonic steroids consist of a steroid nucleus and a lactone ring, and their biologi...

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Detalles Bibliográficos
Autores principales: Rocha, Sayonarah C., Pessoa, Marco T. C., Neves, Luiza D. R., Alves, Silmara L. G., Silva, Luciana M., Santos, Herica L., Oliveira, Soraya M. F., Taranto, Alex G., Comar, Moacyr, Gomes, Isabella V., Santos, Fabio V., Paixão, Natasha, Quintas, Luis E. M., Noël, François, Pereira, Antonio F., Tessis, Ana C. S. C., Gomes, Natalia L. S., Moreira, Otacilio C., Rincon-Heredia, Ruth, Varotti, Fernando P., Blanco, Gustavo, Villar, Jose A. F. P., Contreras, Rubén G., Barbosa, Leandro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188576/
https://www.ncbi.nlm.nih.gov/pubmed/25290152
http://dx.doi.org/10.1371/journal.pone.0108776

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