Neonatal NMDA Receptor Blockade Disrupts Spike Timing and Glutamatergic Synapses in Fast Spiking Interneurons in a NMDA Receptor Hypofunction Model of Schizophrenia

The dysfunction of parvalbumin-positive, fast-spiking interneurons (FSI) is considered a primary contributor to the pathophysiology of schizophrenia (SZ), but deficits in FSI physiology have not been explicitly characterized. We show for the first time, that a widely-employed model of schizophrenia...

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Detalles Bibliográficos
Autores principales: Jones, Kevin S., Corbin, Joshua G., Huntsman, Molly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188593/
https://www.ncbi.nlm.nih.gov/pubmed/25290690
http://dx.doi.org/10.1371/journal.pone.0109303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188593/
https://www.ncbi.nlm.nih.gov/pubmed/25290690
http://dx.doi.org/10.1371/journal.pone.0109303

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