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Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase
[Image: see text] Fatty acid synthase (FASN), the sole protein capable of de novo synthesis of free fatty acids, is overexpressed in a wide variety of human cancers and is associated with poor prognosis and aggressiveness of these cancers. Orlistat, an FDA-approved drug for obesity treatment that in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188697/ https://www.ncbi.nlm.nih.gov/pubmed/25309810 http://dx.doi.org/10.1021/cs500956m |