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Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP

BACKGROUND: Although adding rituximab to the chemotherapy regimen of cyclophosphamide, vincristine, doxorubicin, and prednisone (R-CHOP) has improved clinical outcomes of patients with diffuse large B-cell lymphoma (DLBCL), several recent studies have shown that the effect of rituximab is dominantly...

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Autores principales: Kim, Joong-Keun, Chung, Joo-Seop, Shin, Ho-Jin, Song, Moo-Kon, Yi, Ji-Won, Shin, Dong-Hun, Lee, Dae-Sung, Baek, Sung-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188781/
https://www.ncbi.nlm.nih.gov/pubmed/25325035
http://dx.doi.org/10.5045/br.2014.49.3.162
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author Kim, Joong-Keun
Chung, Joo-Seop
Shin, Ho-Jin
Song, Moo-Kon
Yi, Ji-Won
Shin, Dong-Hun
Lee, Dae-Sung
Baek, Sung-Min
author_facet Kim, Joong-Keun
Chung, Joo-Seop
Shin, Ho-Jin
Song, Moo-Kon
Yi, Ji-Won
Shin, Dong-Hun
Lee, Dae-Sung
Baek, Sung-Min
author_sort Kim, Joong-Keun
collection PubMed
description BACKGROUND: Although adding rituximab to the chemotherapy regimen of cyclophosphamide, vincristine, doxorubicin, and prednisone (R-CHOP) has improved clinical outcomes of patients with diffuse large B-cell lymphoma (DLBCL), several recent studies have shown that the effect of rituximab is dominantly in the non-germinal center (non-GC) subtype compared to the germinal center (GC) subtype. Natural killer (NK) cell count, a surrogate marker of immune status, is associated with clinical outcomes in DLBCL patients in the rituximab era. We investigated whether the impact of NK cells on clinical outcomes differed according to the immunophenotype of DLBCL. METHODS: This study analyzed 72 DLBCL patients treated with R-CHOP between January 2010 and January 2014. RESULTS: Low NK cell counts (<100/µL) were associated with poor progression-free survival (PFS) and overall survival (OS) compared to high NK cell counts. In multivariate analysis, low NK cell count was an independent prognostic factor for PFS and OS. However, survival did not significantly differ between the GC and non-GC subtypes. We examined the clinical influence of NK cells according to the immunophenotype and found that low NK cell counts were significantly associated with poor PFS and OS in non-GC cases, but not in GC cases. CONCLUSION: Low NK cell counts at diagnosis are associated with poor clinical outcomes in DLBCL patients treated with R-CHOP therapy. However, the impact is significant only in non-GC subtype DLBCL, not in the GC subtype.
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spelling pubmed-41887812014-10-16 Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP Kim, Joong-Keun Chung, Joo-Seop Shin, Ho-Jin Song, Moo-Kon Yi, Ji-Won Shin, Dong-Hun Lee, Dae-Sung Baek, Sung-Min Blood Res Original Article BACKGROUND: Although adding rituximab to the chemotherapy regimen of cyclophosphamide, vincristine, doxorubicin, and prednisone (R-CHOP) has improved clinical outcomes of patients with diffuse large B-cell lymphoma (DLBCL), several recent studies have shown that the effect of rituximab is dominantly in the non-germinal center (non-GC) subtype compared to the germinal center (GC) subtype. Natural killer (NK) cell count, a surrogate marker of immune status, is associated with clinical outcomes in DLBCL patients in the rituximab era. We investigated whether the impact of NK cells on clinical outcomes differed according to the immunophenotype of DLBCL. METHODS: This study analyzed 72 DLBCL patients treated with R-CHOP between January 2010 and January 2014. RESULTS: Low NK cell counts (<100/µL) were associated with poor progression-free survival (PFS) and overall survival (OS) compared to high NK cell counts. In multivariate analysis, low NK cell count was an independent prognostic factor for PFS and OS. However, survival did not significantly differ between the GC and non-GC subtypes. We examined the clinical influence of NK cells according to the immunophenotype and found that low NK cell counts were significantly associated with poor PFS and OS in non-GC cases, but not in GC cases. CONCLUSION: Low NK cell counts at diagnosis are associated with poor clinical outcomes in DLBCL patients treated with R-CHOP therapy. However, the impact is significant only in non-GC subtype DLBCL, not in the GC subtype. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014-09 2014-09-25 /pmc/articles/PMC4188781/ /pubmed/25325035 http://dx.doi.org/10.5045/br.2014.49.3.162 Text en © 2014 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Joong-Keun
Chung, Joo-Seop
Shin, Ho-Jin
Song, Moo-Kon
Yi, Ji-Won
Shin, Dong-Hun
Lee, Dae-Sung
Baek, Sung-Min
Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP
title Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP
title_full Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP
title_fullStr Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP
title_full_unstemmed Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP
title_short Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP
title_sort influence of nk cell count on the survival of patients with diffuse large b-cell lymphoma treated with r-chop
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188781/
https://www.ncbi.nlm.nih.gov/pubmed/25325035
http://dx.doi.org/10.5045/br.2014.49.3.162
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