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Primary xanthoma of calcaneus bone: Case report

INTRODUCTION: Xanthoma (or xanthofibroma) is a benign proliferative lesion, mostly seen in soft tissue. Xanthoma of bone is very rare benign primary bone tumor, more frequently seen in men and in patients over 20 years of age. Histologically, it is characterized by mononuclear macrophage-like cells,...

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Autores principales: Ahmed, Ghalib, Al Dosari, Mohammed, El-Mahi, Muatasim, Abolfotouh, Sameh M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189060/
https://www.ncbi.nlm.nih.gov/pubmed/25194608
http://dx.doi.org/10.1016/j.ijscr.2014.07.016
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author Ahmed, Ghalib
Al Dosari, Mohammed
El-Mahi, Muatasim
Abolfotouh, Sameh M.
author_facet Ahmed, Ghalib
Al Dosari, Mohammed
El-Mahi, Muatasim
Abolfotouh, Sameh M.
author_sort Ahmed, Ghalib
collection PubMed
description INTRODUCTION: Xanthoma (or xanthofibroma) is a benign proliferative lesion, mostly seen in soft tissue. Xanthoma of bone is very rare benign primary bone tumor, more frequently seen in men and in patients over 20 years of age. Histologically, it is characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells. It is sometimes discovered coincidentally and the most frequent symptom is pain. PRESENTATION OF CASE: We present a 50-year-old healthy male patient with primary xanthoma of the calcaneus, who was treated by curettage and bone cement. He presented with a pathological fracture in a calcaneus bone lesion. Giant cell tumor was suspected on X-ray and MRI. Curettage and bone cementing was done through the posterolateral approach. Lipid profile was normal and histological examination revealed findings consistent with primary xanthoma of calcaneus bone. DISCUSSION: To avoid an erroneous diagnosis, all material should be examined microscopically, the radiological features of the lesion should be studied properly and lipid profile should be investigated to differentiate between primary and secondary xanthoma. Primary xanthoma may be treated with curettage and bone graft while secondary xanthoma is treated nonsurgically and the skeletal manifestations will disappear with systemic treatment of hyperlipidemia. CONCLUSION: We present this case to raise the suspicion of this lesion that is rarely described in the literatures. This is the first case of primary xanthoma of calcaneus bone that has been reported in Qatar.
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spelling pubmed-41890602014-10-13 Primary xanthoma of calcaneus bone: Case report Ahmed, Ghalib Al Dosari, Mohammed El-Mahi, Muatasim Abolfotouh, Sameh M. Int J Surg Case Rep Article INTRODUCTION: Xanthoma (or xanthofibroma) is a benign proliferative lesion, mostly seen in soft tissue. Xanthoma of bone is very rare benign primary bone tumor, more frequently seen in men and in patients over 20 years of age. Histologically, it is characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells. It is sometimes discovered coincidentally and the most frequent symptom is pain. PRESENTATION OF CASE: We present a 50-year-old healthy male patient with primary xanthoma of the calcaneus, who was treated by curettage and bone cement. He presented with a pathological fracture in a calcaneus bone lesion. Giant cell tumor was suspected on X-ray and MRI. Curettage and bone cementing was done through the posterolateral approach. Lipid profile was normal and histological examination revealed findings consistent with primary xanthoma of calcaneus bone. DISCUSSION: To avoid an erroneous diagnosis, all material should be examined microscopically, the radiological features of the lesion should be studied properly and lipid profile should be investigated to differentiate between primary and secondary xanthoma. Primary xanthoma may be treated with curettage and bone graft while secondary xanthoma is treated nonsurgically and the skeletal manifestations will disappear with systemic treatment of hyperlipidemia. CONCLUSION: We present this case to raise the suspicion of this lesion that is rarely described in the literatures. This is the first case of primary xanthoma of calcaneus bone that has been reported in Qatar. Elsevier 2014-08-15 /pmc/articles/PMC4189060/ /pubmed/25194608 http://dx.doi.org/10.1016/j.ijscr.2014.07.016 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Ahmed, Ghalib
Al Dosari, Mohammed
El-Mahi, Muatasim
Abolfotouh, Sameh M.
Primary xanthoma of calcaneus bone: Case report
title Primary xanthoma of calcaneus bone: Case report
title_full Primary xanthoma of calcaneus bone: Case report
title_fullStr Primary xanthoma of calcaneus bone: Case report
title_full_unstemmed Primary xanthoma of calcaneus bone: Case report
title_short Primary xanthoma of calcaneus bone: Case report
title_sort primary xanthoma of calcaneus bone: case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189060/
https://www.ncbi.nlm.nih.gov/pubmed/25194608
http://dx.doi.org/10.1016/j.ijscr.2014.07.016
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