A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review

Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as n...

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Autores principales: Lee, Hae-Lim, Cho, Sung-Yeon, Lee, Dong-Gun, Ko, Yumi, Hyun, Ji In, Kim, Bo Kyoung, Seo, Jae Hyun, Lee, Jung Woo, Lee, Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189134/
https://www.ncbi.nlm.nih.gov/pubmed/25298910
http://dx.doi.org/10.3947/ic.2014.46.3.199
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author Lee, Hae-Lim
Cho, Sung-Yeon
Lee, Dong-Gun
Ko, Yumi
Hyun, Ji In
Kim, Bo Kyoung
Seo, Jae Hyun
Lee, Jung Woo
Lee, Seok
author_facet Lee, Hae-Lim
Cho, Sung-Yeon
Lee, Dong-Gun
Ko, Yumi
Hyun, Ji In
Kim, Bo Kyoung
Seo, Jae Hyun
Lee, Jung Woo
Lee, Seok
author_sort Lee, Hae-Lim
collection PubMed
description Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation.
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spelling pubmed-41891342014-10-08 A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review Lee, Hae-Lim Cho, Sung-Yeon Lee, Dong-Gun Ko, Yumi Hyun, Ji In Kim, Bo Kyoung Seo, Jae Hyun Lee, Jung Woo Lee, Seok Infect Chemother Case Report Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2014-09 2014-09-24 /pmc/articles/PMC4189134/ /pubmed/25298910 http://dx.doi.org/10.3947/ic.2014.46.3.199 Text en Copyright © 2014 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Hae-Lim
Cho, Sung-Yeon
Lee, Dong-Gun
Ko, Yumi
Hyun, Ji In
Kim, Bo Kyoung
Seo, Jae Hyun
Lee, Jung Woo
Lee, Seok
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review
title A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review
title_full A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review
title_fullStr A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review
title_full_unstemmed A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review
title_short A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review
title_sort fatal spontaneous gas gangrene due to clostridium perfringens during neutropenia of allogeneic stem cell transplantation: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189134/
https://www.ncbi.nlm.nih.gov/pubmed/25298910
http://dx.doi.org/10.3947/ic.2014.46.3.199
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