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Exosomes: A Potential Key Target in Cardio-Renal Syndrome
Exosomes have proven roles in regulating immune response, antigen presentation, RNA and protein transfer, and cell–cell (organ–organ) interaction/signaling. These microvesicles can be considered a mechanism of non-classical secretion of proteins, and they represent a subproteome, thus assisting in t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189416/ https://www.ncbi.nlm.nih.gov/pubmed/25339951 http://dx.doi.org/10.3389/fimmu.2014.00465 |
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author | Gonzalez-Calero, Laura Martin-Lorenzo, Marta Alvarez-Llamas, Gloria |
author_facet | Gonzalez-Calero, Laura Martin-Lorenzo, Marta Alvarez-Llamas, Gloria |
author_sort | Gonzalez-Calero, Laura |
collection | PubMed |
description | Exosomes have proven roles in regulating immune response, antigen presentation, RNA and protein transfer, and cell–cell (organ–organ) interaction/signaling. These microvesicles can be considered a mechanism of non-classical secretion of proteins, and they represent a subproteome, thus assisting in the difficult task of biomarker discovery in a biological fluid as urine, plasma, or serum. A potential role of exosomes in the cardio-renal syndrome is currently underexplored. Cardiovascular disease continues to be the leading cause of morbidity and mortality worldwide and, particularly, rates of cardiovascular events and death consistently increase as kidney function worsens. In other words, chronic kidney disease acts as a risk multiplier. Unfortunately, the relationship between markers of cardiovascular risk in kidney pathology often differs from that in the general population. Efforts in the search for novel action mechanisms simultaneously operating in both pathologies are thus of maximum interest. This article focuses to the role of exosomes in cardiovascular and renal diseases, in the search for novel key targets of interaction between heart and kidneys. |
format | Online Article Text |
id | pubmed-4189416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41894162014-10-22 Exosomes: A Potential Key Target in Cardio-Renal Syndrome Gonzalez-Calero, Laura Martin-Lorenzo, Marta Alvarez-Llamas, Gloria Front Immunol Immunology Exosomes have proven roles in regulating immune response, antigen presentation, RNA and protein transfer, and cell–cell (organ–organ) interaction/signaling. These microvesicles can be considered a mechanism of non-classical secretion of proteins, and they represent a subproteome, thus assisting in the difficult task of biomarker discovery in a biological fluid as urine, plasma, or serum. A potential role of exosomes in the cardio-renal syndrome is currently underexplored. Cardiovascular disease continues to be the leading cause of morbidity and mortality worldwide and, particularly, rates of cardiovascular events and death consistently increase as kidney function worsens. In other words, chronic kidney disease acts as a risk multiplier. Unfortunately, the relationship between markers of cardiovascular risk in kidney pathology often differs from that in the general population. Efforts in the search for novel action mechanisms simultaneously operating in both pathologies are thus of maximum interest. This article focuses to the role of exosomes in cardiovascular and renal diseases, in the search for novel key targets of interaction between heart and kidneys. Frontiers Media S.A. 2014-10-08 /pmc/articles/PMC4189416/ /pubmed/25339951 http://dx.doi.org/10.3389/fimmu.2014.00465 Text en Copyright © 2014 Gonzalez-Calero, Martin-Lorenzo and Alvarez-Llamas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gonzalez-Calero, Laura Martin-Lorenzo, Marta Alvarez-Llamas, Gloria Exosomes: A Potential Key Target in Cardio-Renal Syndrome |
title | Exosomes: A Potential Key Target in Cardio-Renal Syndrome |
title_full | Exosomes: A Potential Key Target in Cardio-Renal Syndrome |
title_fullStr | Exosomes: A Potential Key Target in Cardio-Renal Syndrome |
title_full_unstemmed | Exosomes: A Potential Key Target in Cardio-Renal Syndrome |
title_short | Exosomes: A Potential Key Target in Cardio-Renal Syndrome |
title_sort | exosomes: a potential key target in cardio-renal syndrome |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189416/ https://www.ncbi.nlm.nih.gov/pubmed/25339951 http://dx.doi.org/10.3389/fimmu.2014.00465 |
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