Cargando…

Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule

Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous tox...

Descripción completa

Detalles Bibliográficos
Autores principales: Alfishawy, Mostafa, Anwar, Karim, Elbendary, Amira, Daoud, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189516/
https://www.ncbi.nlm.nih.gov/pubmed/25309761
http://dx.doi.org/10.1155/2014/474359
_version_ 1782338377029255168
author Alfishawy, Mostafa
Anwar, Karim
Elbendary, Amira
Daoud, Ahmed
author_facet Alfishawy, Mostafa
Anwar, Karim
Elbendary, Amira
Daoud, Ahmed
author_sort Alfishawy, Mostafa
collection PubMed
description Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous toxic nodule. Case Presentation. A 51-year-old woman was evaluated for blisters and erosions that develop on her trunk, face, and extremities, with a five-year history of progressively enlarging neck mass, and a past medical history of pemphigus vulgaris seven years ago. The condition was associated with palpitation, dyspnea, and heat intolerance. Thyroid function tests and thyroid scan were compatible with the diagnosis of thyrotoxicosis due to autonomous toxic nodule. Exacerbation of pemphigus vulgaris was proved by skin biopsy from the patient which revealed histologic picture of pemphigus vulgaris. Conclusion. Autoimmune thyroid diseases are reported to associate pemphigus vulgaris. To our knowledge, this case is the first in the English literature to report association between pemphigus vulgaris and autonomous toxic nodule and highlights the possibility of occurrence of pemphigus vulgaris with a nonautoimmune thyroid disease raising the question: is it just a coincidence or is there an explanation for the occurrence of both conditions together?
format Online
Article
Text
id pubmed-4189516
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41895162014-10-12 Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule Alfishawy, Mostafa Anwar, Karim Elbendary, Amira Daoud, Ahmed Case Rep Endocrinol Case Report Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous toxic nodule. Case Presentation. A 51-year-old woman was evaluated for blisters and erosions that develop on her trunk, face, and extremities, with a five-year history of progressively enlarging neck mass, and a past medical history of pemphigus vulgaris seven years ago. The condition was associated with palpitation, dyspnea, and heat intolerance. Thyroid function tests and thyroid scan were compatible with the diagnosis of thyrotoxicosis due to autonomous toxic nodule. Exacerbation of pemphigus vulgaris was proved by skin biopsy from the patient which revealed histologic picture of pemphigus vulgaris. Conclusion. Autoimmune thyroid diseases are reported to associate pemphigus vulgaris. To our knowledge, this case is the first in the English literature to report association between pemphigus vulgaris and autonomous toxic nodule and highlights the possibility of occurrence of pemphigus vulgaris with a nonautoimmune thyroid disease raising the question: is it just a coincidence or is there an explanation for the occurrence of both conditions together? Hindawi Publishing Corporation 2014 2014-09-21 /pmc/articles/PMC4189516/ /pubmed/25309761 http://dx.doi.org/10.1155/2014/474359 Text en Copyright © 2014 Mostafa Alfishawy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alfishawy, Mostafa
Anwar, Karim
Elbendary, Amira
Daoud, Ahmed
Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule
title Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule
title_full Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule
title_fullStr Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule
title_full_unstemmed Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule
title_short Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule
title_sort pemphigus vulgaris with solitary toxic thyroid nodule
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189516/
https://www.ncbi.nlm.nih.gov/pubmed/25309761
http://dx.doi.org/10.1155/2014/474359
work_keys_str_mv AT alfishawymostafa pemphigusvulgariswithsolitarytoxicthyroidnodule
AT anwarkarim pemphigusvulgariswithsolitarytoxicthyroidnodule
AT elbendaryamira pemphigusvulgariswithsolitarytoxicthyroidnodule
AT daoudahmed pemphigusvulgariswithsolitarytoxicthyroidnodule