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Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule
Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous tox...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189516/ https://www.ncbi.nlm.nih.gov/pubmed/25309761 http://dx.doi.org/10.1155/2014/474359 |
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author | Alfishawy, Mostafa Anwar, Karim Elbendary, Amira Daoud, Ahmed |
author_facet | Alfishawy, Mostafa Anwar, Karim Elbendary, Amira Daoud, Ahmed |
author_sort | Alfishawy, Mostafa |
collection | PubMed |
description | Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous toxic nodule. Case Presentation. A 51-year-old woman was evaluated for blisters and erosions that develop on her trunk, face, and extremities, with a five-year history of progressively enlarging neck mass, and a past medical history of pemphigus vulgaris seven years ago. The condition was associated with palpitation, dyspnea, and heat intolerance. Thyroid function tests and thyroid scan were compatible with the diagnosis of thyrotoxicosis due to autonomous toxic nodule. Exacerbation of pemphigus vulgaris was proved by skin biopsy from the patient which revealed histologic picture of pemphigus vulgaris. Conclusion. Autoimmune thyroid diseases are reported to associate pemphigus vulgaris. To our knowledge, this case is the first in the English literature to report association between pemphigus vulgaris and autonomous toxic nodule and highlights the possibility of occurrence of pemphigus vulgaris with a nonautoimmune thyroid disease raising the question: is it just a coincidence or is there an explanation for the occurrence of both conditions together? |
format | Online Article Text |
id | pubmed-4189516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41895162014-10-12 Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule Alfishawy, Mostafa Anwar, Karim Elbendary, Amira Daoud, Ahmed Case Rep Endocrinol Case Report Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous toxic nodule. Case Presentation. A 51-year-old woman was evaluated for blisters and erosions that develop on her trunk, face, and extremities, with a five-year history of progressively enlarging neck mass, and a past medical history of pemphigus vulgaris seven years ago. The condition was associated with palpitation, dyspnea, and heat intolerance. Thyroid function tests and thyroid scan were compatible with the diagnosis of thyrotoxicosis due to autonomous toxic nodule. Exacerbation of pemphigus vulgaris was proved by skin biopsy from the patient which revealed histologic picture of pemphigus vulgaris. Conclusion. Autoimmune thyroid diseases are reported to associate pemphigus vulgaris. To our knowledge, this case is the first in the English literature to report association between pemphigus vulgaris and autonomous toxic nodule and highlights the possibility of occurrence of pemphigus vulgaris with a nonautoimmune thyroid disease raising the question: is it just a coincidence or is there an explanation for the occurrence of both conditions together? Hindawi Publishing Corporation 2014 2014-09-21 /pmc/articles/PMC4189516/ /pubmed/25309761 http://dx.doi.org/10.1155/2014/474359 Text en Copyright © 2014 Mostafa Alfishawy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Alfishawy, Mostafa Anwar, Karim Elbendary, Amira Daoud, Ahmed Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule |
title | Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule |
title_full | Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule |
title_fullStr | Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule |
title_full_unstemmed | Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule |
title_short | Pemphigus Vulgaris with Solitary Toxic Thyroid Nodule |
title_sort | pemphigus vulgaris with solitary toxic thyroid nodule |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189516/ https://www.ncbi.nlm.nih.gov/pubmed/25309761 http://dx.doi.org/10.1155/2014/474359 |
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