Cargando…

Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling

BACKGROUND: Pancreatic cancer is a leading cause of cancer-related deaths in the world with a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy for advanced pancreatic cancer, and new effective strategies are urgently needed. Recently, an arginine deprivati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jiangbo, Ma, Jiguang, Wu, Zheng, Li, Wei, Zhang, Dong, Han, Liang, Wang, Fengfei, Reindl, Katie M, Wu, Erxi, Ma, Qingyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189535/ https://www.ncbi.nlm.nih.gov/pubmed/25240403 http://dx.doi.org/10.1186/1471-2407-14-686

Ejemplares similares

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase
por: Kelly, M P, et al.
Publicado: (2012)

RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells
por: Wu, Fe-Lin Lin, et al.
Publicado: (2011)

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase
por: Feun, L G, et al.
Publicado: (2012)

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis
por: Delage, B, et al.
Publicado: (2012)

Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy
por: McAlpine, Jennifer A, et al.
Publicado: (2014)

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1–Deficient Thoracic Cancers
por: Beddowes, Emma, et al.
Publicado: (2017)

The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
por: Savaraj, Niramol, et al.
Publicado: (2007)

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin
por: Savaraj, Niramol, et al.
Publicado: (2015)

The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma
por: Thongkum, Angkana, et al.
Publicado: (2017)

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma
por: Syed, N, et al.
Publicado: (2013)

Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines
por: Shan, Yan-Shen, et al.
Publicado: (2015)

Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression
por: Kim, Stephanie S., et al.
Publicado: (2020)

Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
por: Daylami, Rouzbeh, et al.
Publicado: (2014)

Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis
por: van der Meer, Jonathan H. M., et al.
Publicado: (2021)

Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1
por: Zhou, Cancan, et al.
Publicado: (2018)

A transgenic approach to study argininosuccinate synthetase gene expression
por: Shiue, Shih-Chang, et al.
Publicado: (2014)

Differential expression of argininosuccinate synthetase in serous and non‐serous ovarian carcinomas
por: Cheon, Dong‐Joo, et al.
Publicado: (2014)

Argininosuccinate synthase 1, arginine deprivation therapy and cancer management
por: Sun, Naihui, et al.
Publicado: (2022)

β(2)-adrenoceptor blockage induces G(1)/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway
por: Zhang, Dong, et al.
Publicado: (2011)

Cytosolic Delivery of Argininosuccinate Synthetase Using a Cell-Permeant Miniature Protein
por: Knox, Susan L., et al.
Publicado: (2021)

Arginine metabolism and the role of arginine deiminase-producing microorganisms in kimchi fermentation
por: Jung, Sera, et al.
Publicado: (2022)

Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer
por: SHAN, YAN-SHEN, et al.
Publicado: (2015)

Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance
por: Kim, Youngji, et al.
Publicado: (2016)

Depletion of Arginine by Recombinant Arginine Deiminase Induces nNOS-Activated Neurotoxicity in Neuroblastoma Cells
por: Lin, Shan-Erh, et al.
Publicado: (2014)

Pegylated Arginine Deiminase Downregulates Colitis in Murine Models
por: Oz, Helieh S., et al.
Publicado: (2012)

Multilevel Approach for the Treatment of Giardiasis by Targeting Arginine Deiminase
por: Fernández-Lainez, Cynthia, et al.
Publicado: (2021)

Streptococcal Arginine Deiminase Inhibits T Lymphocyte Differentiation In Vitro
por: Starikova, Eleonora A., et al.
Publicado: (2023)

Expression profile and down-regulation of argininosuccinate synthetase in hepatocellular carcinoma in a transgenic mouse model
por: Shiue, Shih-Chang, et al.
Publicado: (2015)

Citrullinemia type I in Chinese children: Identification of two novel argininosuccinate synthetase gene mutations
por: Xiong, Mei, et al.
Publicado: (2022)

Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
por: Zhang, Yiming, et al.
Publicado: (2022)

Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury
por: Du, Mingjun, et al.
Publicado: (2020)

Arginine deiminase: a potential inhibitor of angiogenesis and tumour growth
por: Park, I-S, et al.
Publicado: (2003)

Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor
por: Aliko, Ardita, et al.
Publicado: (2019)

PEGylation increases antitumoral activity of arginine deiminase of Streptococcus pyogenes
por: Schwarz, Rico, et al.
Publicado: (2021)

High-throughput enrichment of temperature-sensitive argininosuccinate synthetase for two-stage citrulline production in E. coli
por: Schramm, Thorben, et al.
Publicado: (2020)

Convergent evolution of the arginine deiminase pathway: the ArcD and ArcE arginine/ornithine exchangers
por: Noens, Elke E. E., et al.
Publicado: (2016)

Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer
por: Beato, Miguel, et al.
Publicado: (2020)

Suppression of IL-6 Gene by shRNA Augments Gemcitabine Chemosensitization in Pancreatic Adenocarcinoma Cells
por: Xing, Hai-Bo, et al.
Publicado: (2018)

Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway
por: Zhang, Juan, et al.
Publicado: (2022)

Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma
por: Liu, Qingqing, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_lbrn9ggnthhsnimb0437nmkr62