Cargando…

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS

Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-/RNA-binding protein that is involved in a variety of cellular functions including transcription, protein translation, RNA splicing, and transport. FUS was initially identified as a fusion oncoprotein, and thus, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sama, Reddy Ranjith Kumar, Ward, Catherine L., Bosco, Daryl A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2014
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189536/ https://www.ncbi.nlm.nih.gov/pubmed/25289647 http://dx.doi.org/10.1177/1759091414544472

Ejemplares similares

Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
por: Baron, Desiree M, et al.
Publicado: (2013)

TLS/FUS: A protein in cancer and ALS
por: Tan, Adelene Y., et al.
Publicado: (2012)

A Yeast Model of FUS/TLS-Dependent Cytotoxicity
por: Ju, Shulin, et al.
Publicado: (2011)

A loss of FUS/TLS function leads to impaired cellular proliferation
por: Ward, C L, et al.
Publicado: (2014)

ALS mutations in TLS/FUS disrupt target gene expression
por: Coady, Tristan H., et al.
Publicado: (2015)

Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
por: Sun, Zhihui, et al.
Publicado: (2011)

FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses
por: Xue, Yuan Chao, et al.
Publicado: (2021)

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation
por: Sama, Reddy Ranjith K., et al.
Publicado: (2017)

FUS/TLS Is a Co-Activator of Androgen Receptor in Prostate Cancer Cells
por: Haile, Simon, et al.
Publicado: (2011)

FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice
por: Kino, Yoshihiro, et al.
Publicado: (2016)

RNA sequence and length contribute to RNA-induced conformational change of TLS/FUS
por: Hamad, Nesreen, et al.
Publicado: (2020)

ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
por: Sun, Shuying, et al.
Publicado: (2015)

Plastic roles of phenylalanine and tyrosine residues of TLS/FUS in complex formation with the G-quadruplexes of telomeric DNA and TERRA
por: Kondo, Keiko, et al.
Publicado: (2018)

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage
por: Rulten, Stuart L., et al.
Publicado: (2014)

FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis
por: Kino, Yoshihiro, et al.
Publicado: (2015)

G-quadruplex binding ability of TLS/FUS depends on the β-spiral structure of the RGG domain
por: Yagi, Ryota, et al.
Publicado: (2018)

The Effect of PRMT1-Mediated Arginine Methylation on the Subcellular Localization, Stress Granules, and Detergent-Insoluble Aggregates of FUS/TLS
por: Yamaguchi, Atsushi, et al.
Publicado: (2012)

m(6)A Modified Short RNA Fragments Inhibit Cytoplasmic TLS/FUS Aggregation Induced by Hyperosmotic Stress
por: Yoneda, Ryoma, et al.
Publicado: (2021)

Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations
por: Kino, Yoshihiro, et al.
Publicado: (2011)

Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for its Anti-proliferative Activity
por: Oh, Sang-Muk, et al.
Publicado: (2009)

The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots
por: Giannattasio, Teresa, et al.
Publicado: (2023)

Automatic Registration of TLS-TLS and TLS-MLS Point Clouds Using a Genetic Algorithm
por: Yan, Li, et al.
Publicado: (2017)

SSL and TLS
por: Oppliger, Rolf
Publicado: (2016)

DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2
por: Bento, Christoffer, et al.
Publicado: (2009)

rTLS: Secure and Efficient TLS Session Resumption for the Internet of Things †
por: Tange, Koen, et al.
Publicado: (2021)

FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration
por: Kodavati, Manohar, et al.
Publicado: (2023)

FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factors
por: Raczynska, Katarzyna Dorota, et al.
Publicado: (2015)

Changes in the Expression of FUS/TLS in Spinal Cords of SOD1 G93A Transgenic Mice and Correlation with Motor-Neuron Degeneration
por: Li, Jiao, et al.
Publicado: (2016)

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules
por: Vance, Caroline, et al.
Publicado: (2013)

FUS-NLS/Transportin 1 Complex Structure Provides Insights into the Nuclear Targeting Mechanism of FUS and the Implications in ALS
por: Niu, Chunyan, et al.
Publicado: (2012)

Turning Tertiary Lymphoid Structures (TLS) into Hot Spots: Values of TLS in Gastrointestinal Tumors
por: Cai, Daming, et al.
Publicado: (2023)

TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review
por: Zhang, Heyang, et al.
Publicado: (2022)

SSL and TLS: Theory and Practice
por: Oppliger, Rolf
Publicado: (2009)

Local Feedback Application in TLS
por: Kuo, C H, et al.
Publicado: (1999)

Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS
por: An, Haiyan, et al.
Publicado: (2020)

Does ALS‐FUS without FUS mutation represent ALS‐FET? Report of three cases
por: Borrego‐Écija, S., et al.
Publicado: (2018)

ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation
por: King, Andrew, et al.
Publicado: (2015)

Importance of Functional Loss of FUS in FTLD/ALS
por: Ishigaki, Shinsuke, et al.
Publicado: (2018)

ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation
por: Zhou, Yueqin, et al.
Publicado: (2013)

Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins
por: Alves, Sandro, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mel33tciubp50deqnhumgs8o2l