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Diverse modes of genomic alteration in hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is a heterogeneous disease with high mortality rate. Recent genomic studies have identified TP53, AXIN1, and CTNNB1 as the most frequently mutated genes. Lower frequency mutations have been reported in ARID1A, ARID2 and JAK1. In addition, hepatitis B virus...

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Detalles Bibliográficos
Autores principales:	Jhunjhunwala, Suchit, Jiang, Zhaoshi, Stawiski, Eric W, Gnad, Florian, Liu, Jinfeng, Mayba, Oleg, Du, Pan, Diao, Jingyu, Johnson, Stephanie, Wong, Kwong-Fai, Gao, Zhibo, Li, Yingrui, Wu, Thomas D, Kapadia, Sharookh B, Modrusan, Zora, French, Dorothy M, Luk, John M, Seshagiri, Somasekar, Zhang, Zemin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189592/ https://www.ncbi.nlm.nih.gov/pubmed/25159915 http://dx.doi.org/10.1186/s13059-014-0436-9

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