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Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations

BACKGROUND: Cerebral ischemic stroke (CIS) is a major cause of morbidity and mortality. Its main pathological basis is atherosclerosis (AS); in turn, the main risk factor in AS is dyslipidemia. Human proprotein convertase subtilisin/kexin9 (PCSK9) plays a key role in regulating plasma low-density li...

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Autores principales: Han, Dengfeng, Ma, Jianhua, Zhang, Xiaoning, Cai, Jian, Li, Jinlan, Tuerxun, Tuerhong, Hao, Chenguang, Du, Lei, Lei, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189717/
https://www.ncbi.nlm.nih.gov/pubmed/25266949
http://dx.doi.org/10.12659/MSM.892091
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author Han, Dengfeng
Ma, Jianhua
Zhang, Xiaoning
Cai, Jian
Li, Jinlan
Tuerxun, Tuerhong
Hao, Chenguang
Du, Lei
Lei, Jing
author_facet Han, Dengfeng
Ma, Jianhua
Zhang, Xiaoning
Cai, Jian
Li, Jinlan
Tuerxun, Tuerhong
Hao, Chenguang
Du, Lei
Lei, Jing
author_sort Han, Dengfeng
collection PubMed
description BACKGROUND: Cerebral ischemic stroke (CIS) is a major cause of morbidity and mortality. Its main pathological basis is atherosclerosis (AS); in turn, the main risk factor in AS is dyslipidemia. Human proprotein convertase subtilisin/kexin9 (PCSK9) plays a key role in regulating plasma low-density lipoprotein (LDL) cholesterol levels. We sought to assess the association between PCSK9 and CIS in Chinese Han and Uygur populations. MATERIAL/METHODS: We selected 408 CIS patients and 348 control subjects and used a single-base terminal extension (SNaPshot) method to detect the genotypes of the 20 single-nucleotide polymorphisms (SNPs) in PCSK9. RESULTS: Distribution of SNP8 (rs529787) genotypes showed a significant difference between CIS and control participants (P=0.049). However, when analyzing Han and Uygur populations separately, we found that only Han subjects showed distribution of SNP1 (rs1711503), SNP2 (rs2479408), and SNP8 (rs529787) alleles that was significantly different between CIS and control participants (P=0.028, P=0.013, P=0.006, respectively), and distribution of SNP2 (rs2479408) in the dominant model (CC vs. CG + GG) was significantly different between CIS and control participants (P=0.013), even after adjustment for covariates (OR: 75.262, 95% confidence interval [CI]: 7.232–783.278, P<0.001). Distribution of the 2 haplotypes (A-C and G-C) (rs1711503 and rs2479408) was significantly different between CIS and control participants (both, P=0.011). CONCLUSIONS: Both rs1711503 and rs2479408 of PCSK9 genes were associated with CIS in the Han population of China. A-C haplotype may be a genetic marker of CIS risk in this population.
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spelling pubmed-41897172014-10-09 Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations Han, Dengfeng Ma, Jianhua Zhang, Xiaoning Cai, Jian Li, Jinlan Tuerxun, Tuerhong Hao, Chenguang Du, Lei Lei, Jing Med Sci Monit Clinical Research BACKGROUND: Cerebral ischemic stroke (CIS) is a major cause of morbidity and mortality. Its main pathological basis is atherosclerosis (AS); in turn, the main risk factor in AS is dyslipidemia. Human proprotein convertase subtilisin/kexin9 (PCSK9) plays a key role in regulating plasma low-density lipoprotein (LDL) cholesterol levels. We sought to assess the association between PCSK9 and CIS in Chinese Han and Uygur populations. MATERIAL/METHODS: We selected 408 CIS patients and 348 control subjects and used a single-base terminal extension (SNaPshot) method to detect the genotypes of the 20 single-nucleotide polymorphisms (SNPs) in PCSK9. RESULTS: Distribution of SNP8 (rs529787) genotypes showed a significant difference between CIS and control participants (P=0.049). However, when analyzing Han and Uygur populations separately, we found that only Han subjects showed distribution of SNP1 (rs1711503), SNP2 (rs2479408), and SNP8 (rs529787) alleles that was significantly different between CIS and control participants (P=0.028, P=0.013, P=0.006, respectively), and distribution of SNP2 (rs2479408) in the dominant model (CC vs. CG + GG) was significantly different between CIS and control participants (P=0.013), even after adjustment for covariates (OR: 75.262, 95% confidence interval [CI]: 7.232–783.278, P<0.001). Distribution of the 2 haplotypes (A-C and G-C) (rs1711503 and rs2479408) was significantly different between CIS and control participants (both, P=0.011). CONCLUSIONS: Both rs1711503 and rs2479408 of PCSK9 genes were associated with CIS in the Han population of China. A-C haplotype may be a genetic marker of CIS risk in this population. International Scientific Literature, Inc. 2014-09-30 /pmc/articles/PMC4189717/ /pubmed/25266949 http://dx.doi.org/10.12659/MSM.892091 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Han, Dengfeng
Ma, Jianhua
Zhang, Xiaoning
Cai, Jian
Li, Jinlan
Tuerxun, Tuerhong
Hao, Chenguang
Du, Lei
Lei, Jing
Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations
title Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations
title_full Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations
title_fullStr Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations
title_full_unstemmed Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations
title_short Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations
title_sort correlation of pcsk9 gene polymorphism with cerebral ischemic stroke in xinjiang han and uygur populations
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189717/
https://www.ncbi.nlm.nih.gov/pubmed/25266949
http://dx.doi.org/10.12659/MSM.892091
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