Cargando…

Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

To investigate the role of E23K polymorphism of the KCNJ11 gene on early onset of type 2 diabetes in school-aged children/adolescents in Taiwan, we recruited 38 subjects with type 2 diabetes (ages 18.6 ± 6.6 years; body mass index percentiles 83.3 ± 15.4) and 69 normal controls (ages 17.3 ± 3.8 year...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Yi-Der, Chuang, Lee-Ming, Pei, Dee, Lee, Yann-Jinn, Wei, Jun-Nan, Sung, Fung-Chang, Chang, Tien-Jyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189766/ https://www.ncbi.nlm.nih.gov/pubmed/25309595 http://dx.doi.org/10.1155/2014/983016

Ejemplares similares

Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction
por: Yang, Zhong-Wei, et al.
Publicado: (2013)

ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
por: Tricarico, Domenico, et al.
Publicado: (2016)

Stabilization of the Activity of ATP-sensitive Potassium Channels by Ion Pairs Formed between Adjacent Kir6.2 Subunits
por: Lin, Yu-Wen, et al.
Publicado: (2003)

Control of Rectification and Gating of Cloned K(ATP) Channels by the Kir6.2 Subunit
por: Shyng, S.-L., et al.
Publicado: (1997)

Regulation of myometrial contraction by ATP-sensitive potassium (K(ATP)) channel via activation of SUR2B and Kir 6.2 in mouse
por: HONG, Seung Hwa, et al.
Publicado: (2016)

Mutations within the P-Loop of Kir6.2 Modulate the Intraburst Kinetics of the Atp-Sensitive Potassium Channel
por: Proks, Peter, et al.
Publicado: (2001)

A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP(2)-Dependent Gating
por: Bushman, Jeremy D., et al.
Publicado: (2013)

Sulfonylurea and K(+)-Channel Opener Sensitivity of K(ATP) Channels: Functional Coupling of Kir6.2 and Sur1 Subunits
por: Koster, J.C., et al.
Publicado: (1999)

Sulfonylurea Therapy in Two Korean Patients with Insulin-treated Neonatal Diabetes due to Heterozygous Mutations of the KCNJ11 Gene Encoding Kir6.2
por: Kim, Min Sun, et al.
Publicado: (2007)

Congenital Hyperinsulinism and Glucose Hypersensitivity in Homozygous and Heterozygous Carriers of Kir6.2 (KCNJ11) Mutation V290M Mutation: K(ATP) Channel Inactivation Mechanism and Clinical Management
por: Loechner, Karen J., et al.
Publicado: (2011)

Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in K(ATP) channels
por: Pratt, Emily B., et al.
Publicado: (2012)

Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A K(ATP) channels: A mechanistic study
por: Proks, Peter, et al.
Publicado: (2014)

Kir6.2-containing ATP-sensitive K(+) channel is required for cardioprotection of resveratrol in mice
por: Du, Ren-Hong, et al.
Publicado: (2014)

Carvacrol treatment opens Kir6.2 ATP-dependent potassium channels and prevents apoptosis on rat testis following ischemia–reperfusion injury model
por: Balci, Cemre Nur, et al.
Publicado: (2021)

Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy
por: Lin, Ching-Han, et al.
Publicado: (2022)

Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K(+) channels
por: Heitz, Benjamin A., et al.
Publicado: (2021)

CL-705G: a novel chemical Kir6.2-specific K(ATP) channel opener
por: Gando, Ivan, et al.
Publicado: (2023)

MON-187 The E23K Missense Variant of the Gene Encoding the Pancreatic Beta-Cell KATP Channel Subunit Kir6.2 (KCNJ11) Associates with Diabetic Retinopathy and Hyperglycemia Control in Type 2 Diabetes Patients
por: Sarray, Sameh, et al.
Publicado: (2019)

Functional consequences of Kir2.1/Kir2.2 subunit heteromerization
por: Panama, Brian K., et al.
Publicado: (2010)

KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis
por: Nakajima, Ken-ichi, et al.
Publicado: (2015)

Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide
por: Henn, Matthew C, et al.
Publicado: (2015)

A Novel KCNJ2 Mutation Identified in an Autistic Proband Affects the Single Channel Properties of Kir2.1
por: Binda, Anna, et al.
Publicado: (2018)

Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation
por: Song, Nanshan, et al.
Publicado: (2021)

Simulating PIP(2)-Induced Gating Transitions in Kir6.2 Channels
por: Bründl, Michael, et al.
Publicado: (2021)

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16)
por: Trapp, Stefan, et al.
Publicado: (2011)

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the K(ATP) channel
por: Remedi, Maria S., et al.
Publicado: (2017)

Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway
por: Liu, Huanxin, et al.
Publicado: (2015)

Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties
por: Bränström, Robert, et al.
Publicado: (2022)

Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues
por: Principalli, Maria A, et al.
Publicado: (2015)

Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K(ATP) channel complex
por: Brennan, Sean, et al.
Publicado: (2020)

Discovery, Characterization, and Structure–Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1
por: Raphemot, Rene, et al.
Publicado: (2011)

Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis
por: Reilly, Louise, et al.
Publicado: (2021)

Regulation of Cloned Atp-Sensitive K Channels by Adenine Nucleotides and Sulfonylureas: Interactions between Sur1 and Positively Charged Domains on Kir6.2
por: John, Scott A., et al.
Publicado: (2001)

Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotection
por: Wang, Jie, et al.
Publicado: (2023)

Subunit gating resulting from individual protonation events in Kir2 channels
por: Maksaev, Grigory, et al.
Publicado: (2023)

Subunit gating resulting from individual protonation events in Kir2 channels
por: Maksaev, Grigory, et al.
Publicado: (2023)

Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa
por: Poli, Giulia, et al.
Publicado: (2021)

Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels
por: Zangerl-Plessl, Eva-Maria, et al.
Publicado: (2019)

Transient neonatal diabetes due to a missense mutation (E227K) in the gene encoding the ATP-sensitive potassium channel (KCNJ11)
por: Martins, Luísa, et al.
Publicado: (2015)

Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism
por: Shimomura, Kenju, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_mcahs20fagghk07v6j7t66an8e