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EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood worldwide and Mexico has reported one of the highest incidence rates. An infectious etiology has been suggested and supported by epidemiological evidences; however, the identity of the involved agent(s) is not known. We consid...

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Autores principales: Morales-Sánchez, A., Pompa-Mera, E. N., Fajardo-Gutiérrez, A., Alvarez-Rodríguez, F. J., Bekker-Méndez, V. C., Flores-Chapa, J. de Diego, Flores-Lujano, J., Jiménez-Hernández, E., Peñaloza-González, J. G., Rodríguez-Zepeda, M. C., Torres-Nava, J. R., Velázquez-Aviña, M. M., Amador-Sánchez, R., Alvarado-Ibarra, M., Reyes-Zepeda, N., Espinosa-Elizondo, R. M., Pérez-Saldivar, M. L., Núñez-Enríquez, J. C., Mejía-Aranguré, J. M., Fuentes-Pananá, E. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189769/
https://www.ncbi.nlm.nih.gov/pubmed/25309913
http://dx.doi.org/10.1155/2014/548097
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author Morales-Sánchez, A.
Pompa-Mera, E. N.
Fajardo-Gutiérrez, A.
Alvarez-Rodríguez, F. J.
Bekker-Méndez, V. C.
Flores-Chapa, J. de Diego
Flores-Lujano, J.
Jiménez-Hernández, E.
Peñaloza-González, J. G.
Rodríguez-Zepeda, M. C.
Torres-Nava, J. R.
Velázquez-Aviña, M. M.
Amador-Sánchez, R.
Alvarado-Ibarra, M.
Reyes-Zepeda, N.
Espinosa-Elizondo, R. M.
Pérez-Saldivar, M. L.
Núñez-Enríquez, J. C.
Mejía-Aranguré, J. M.
Fuentes-Pananá, E. M.
author_facet Morales-Sánchez, A.
Pompa-Mera, E. N.
Fajardo-Gutiérrez, A.
Alvarez-Rodríguez, F. J.
Bekker-Méndez, V. C.
Flores-Chapa, J. de Diego
Flores-Lujano, J.
Jiménez-Hernández, E.
Peñaloza-González, J. G.
Rodríguez-Zepeda, M. C.
Torres-Nava, J. R.
Velázquez-Aviña, M. M.
Amador-Sánchez, R.
Alvarado-Ibarra, M.
Reyes-Zepeda, N.
Espinosa-Elizondo, R. M.
Pérez-Saldivar, M. L.
Núñez-Enríquez, J. C.
Mejía-Aranguré, J. M.
Fuentes-Pananá, E. M.
author_sort Morales-Sánchez, A.
collection PubMed
description Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood worldwide and Mexico has reported one of the highest incidence rates. An infectious etiology has been suggested and supported by epidemiological evidences; however, the identity of the involved agent(s) is not known. We considered that early transmitted lymphotropic herpes viruses were good candidates, since transforming mechanisms have been described for them and some are already associated with human cancers. In this study we interrogated the direct role of EBV, HCMV, HHV6, and HHV7 human herpes viruses in childhood ALL. Viral genomes were screened in 70 bone marrow samples from ALL patients through standard and a more sensitive nested PCR. Positive samples were detected only by nested PCR indicating a low level of infection. Our result argues that viral genomes were not present in all leukemic cells, and, hence, infection most likely was not part of the initial genetic lesions leading to ALL. The high statistical power of the study suggested that these agents are not involved in the genesis of ALL in Mexican children. Additional analysis showed that detected infections or coinfections were not associated with prognosis.
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spelling pubmed-41897692014-10-12 EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia Morales-Sánchez, A. Pompa-Mera, E. N. Fajardo-Gutiérrez, A. Alvarez-Rodríguez, F. J. Bekker-Méndez, V. C. Flores-Chapa, J. de Diego Flores-Lujano, J. Jiménez-Hernández, E. Peñaloza-González, J. G. Rodríguez-Zepeda, M. C. Torres-Nava, J. R. Velázquez-Aviña, M. M. Amador-Sánchez, R. Alvarado-Ibarra, M. Reyes-Zepeda, N. Espinosa-Elizondo, R. M. Pérez-Saldivar, M. L. Núñez-Enríquez, J. C. Mejía-Aranguré, J. M. Fuentes-Pananá, E. M. Biomed Res Int Research Article Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood worldwide and Mexico has reported one of the highest incidence rates. An infectious etiology has been suggested and supported by epidemiological evidences; however, the identity of the involved agent(s) is not known. We considered that early transmitted lymphotropic herpes viruses were good candidates, since transforming mechanisms have been described for them and some are already associated with human cancers. In this study we interrogated the direct role of EBV, HCMV, HHV6, and HHV7 human herpes viruses in childhood ALL. Viral genomes were screened in 70 bone marrow samples from ALL patients through standard and a more sensitive nested PCR. Positive samples were detected only by nested PCR indicating a low level of infection. Our result argues that viral genomes were not present in all leukemic cells, and, hence, infection most likely was not part of the initial genetic lesions leading to ALL. The high statistical power of the study suggested that these agents are not involved in the genesis of ALL in Mexican children. Additional analysis showed that detected infections or coinfections were not associated with prognosis. Hindawi Publishing Corporation 2014 2014-09-18 /pmc/articles/PMC4189769/ /pubmed/25309913 http://dx.doi.org/10.1155/2014/548097 Text en Copyright © 2014 A. Morales-Sánchez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Morales-Sánchez, A.
Pompa-Mera, E. N.
Fajardo-Gutiérrez, A.
Alvarez-Rodríguez, F. J.
Bekker-Méndez, V. C.
Flores-Chapa, J. de Diego
Flores-Lujano, J.
Jiménez-Hernández, E.
Peñaloza-González, J. G.
Rodríguez-Zepeda, M. C.
Torres-Nava, J. R.
Velázquez-Aviña, M. M.
Amador-Sánchez, R.
Alvarado-Ibarra, M.
Reyes-Zepeda, N.
Espinosa-Elizondo, R. M.
Pérez-Saldivar, M. L.
Núñez-Enríquez, J. C.
Mejía-Aranguré, J. M.
Fuentes-Pananá, E. M.
EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia
title EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia
title_full EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia
title_fullStr EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia
title_full_unstemmed EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia
title_short EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia
title_sort ebv, hcmv, hhv6, and hhv7 screening in bone marrow samples from children with acute lymphoblastic leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189769/
https://www.ncbi.nlm.nih.gov/pubmed/25309913
http://dx.doi.org/10.1155/2014/548097
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