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Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples
We use a systems biology approach to construct protein-protein interaction networks (PPINs) for early and late stage bladder cancer. By comparing the networks of these two stages, we find that both networks showed very significantly different mechanisms. To obtain the differential network structures...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189772/ https://www.ncbi.nlm.nih.gov/pubmed/25309904 http://dx.doi.org/10.1155/2014/159078 |
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author | Wong, Yung-Hao Li, Cheng-Wei Chen, Bor-Sen |
author_facet | Wong, Yung-Hao Li, Cheng-Wei Chen, Bor-Sen |
author_sort | Wong, Yung-Hao |
collection | PubMed |
description | We use a systems biology approach to construct protein-protein interaction networks (PPINs) for early and late stage bladder cancer. By comparing the networks of these two stages, we find that both networks showed very significantly different mechanisms. To obtain the differential network structures between cancer and noncancer PPINs, we constructed cancer PPIN and noncancer PPIN network structures for the two bladder cancer stages using microarray data from cancer cells and their adjacent noncancer cells, respectively. With their carcinogenesis relevance values (CRVs), we identified 152 and 50 significant proteins and their PPI networks (network markers) for early and late stage bladder cancer by statistical assessment. To investigate the evolution of network biomarkers in the carcinogenesis process, primary pathway analysis showed that the significant pathways of early stage bladder cancer are related to ordinary cancer mechanisms, while the ribosome pathway and spliceosome pathway are most important for late stage bladder cancer. Their only intersection is the ubiquitin mediated proteolysis pathway in the whole stage of bladder cancer. The evolution of network biomarkers from early to late stage can reveal the carcinogenesis of bladder cancer. The findings in this study are new clues specific to this study and give us a direction for targeted cancer therapy, and it should be validated in vivo or in vitro in the future. |
format | Online Article Text |
id | pubmed-4189772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41897722014-10-12 Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples Wong, Yung-Hao Li, Cheng-Wei Chen, Bor-Sen Biomed Res Int Research Article We use a systems biology approach to construct protein-protein interaction networks (PPINs) for early and late stage bladder cancer. By comparing the networks of these two stages, we find that both networks showed very significantly different mechanisms. To obtain the differential network structures between cancer and noncancer PPINs, we constructed cancer PPIN and noncancer PPIN network structures for the two bladder cancer stages using microarray data from cancer cells and their adjacent noncancer cells, respectively. With their carcinogenesis relevance values (CRVs), we identified 152 and 50 significant proteins and their PPI networks (network markers) for early and late stage bladder cancer by statistical assessment. To investigate the evolution of network biomarkers in the carcinogenesis process, primary pathway analysis showed that the significant pathways of early stage bladder cancer are related to ordinary cancer mechanisms, while the ribosome pathway and spliceosome pathway are most important for late stage bladder cancer. Their only intersection is the ubiquitin mediated proteolysis pathway in the whole stage of bladder cancer. The evolution of network biomarkers from early to late stage can reveal the carcinogenesis of bladder cancer. The findings in this study are new clues specific to this study and give us a direction for targeted cancer therapy, and it should be validated in vivo or in vitro in the future. Hindawi Publishing Corporation 2014 2014-09-18 /pmc/articles/PMC4189772/ /pubmed/25309904 http://dx.doi.org/10.1155/2014/159078 Text en Copyright © 2014 Yung-Hao Wong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wong, Yung-Hao Li, Cheng-Wei Chen, Bor-Sen Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples |
title | Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples |
title_full | Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples |
title_fullStr | Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples |
title_full_unstemmed | Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples |
title_short | Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples |
title_sort | evolution of network biomarkers from early to late stage bladder cancer samples |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189772/ https://www.ncbi.nlm.nih.gov/pubmed/25309904 http://dx.doi.org/10.1155/2014/159078 |
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