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Passive Broad-Spectrum Influenza Immunoprophylaxis
Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190013/ https://www.ncbi.nlm.nih.gov/pubmed/25328697 http://dx.doi.org/10.1155/2014/267594 |
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author | Berry, Cassandra M. Penhale, William J. Sangster, Mark Y. |
author_facet | Berry, Cassandra M. Penhale, William J. Sangster, Mark Y. |
author_sort | Berry, Cassandra M. |
collection | PubMed |
description | Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. Here, we review passive broad-spectrum influenza prophylaxis options with a focus on harnessing natural host defenses, including interferons and antibodies. |
format | Online Article Text |
id | pubmed-4190013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41900132014-10-19 Passive Broad-Spectrum Influenza Immunoprophylaxis Berry, Cassandra M. Penhale, William J. Sangster, Mark Y. Influenza Res Treat Review Article Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. Here, we review passive broad-spectrum influenza prophylaxis options with a focus on harnessing natural host defenses, including interferons and antibodies. Hindawi Publishing Corporation 2014 2014-09-22 /pmc/articles/PMC4190013/ /pubmed/25328697 http://dx.doi.org/10.1155/2014/267594 Text en Copyright © 2014 Cassandra M. Berry et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Berry, Cassandra M. Penhale, William J. Sangster, Mark Y. Passive Broad-Spectrum Influenza Immunoprophylaxis |
title | Passive Broad-Spectrum Influenza Immunoprophylaxis |
title_full | Passive Broad-Spectrum Influenza Immunoprophylaxis |
title_fullStr | Passive Broad-Spectrum Influenza Immunoprophylaxis |
title_full_unstemmed | Passive Broad-Spectrum Influenza Immunoprophylaxis |
title_short | Passive Broad-Spectrum Influenza Immunoprophylaxis |
title_sort | passive broad-spectrum influenza immunoprophylaxis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190013/ https://www.ncbi.nlm.nih.gov/pubmed/25328697 http://dx.doi.org/10.1155/2014/267594 |
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