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Passive Broad-Spectrum Influenza Immunoprophylaxis

Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include th...

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Detalles Bibliográficos
Autores principales: Berry, Cassandra M., Penhale, William J., Sangster, Mark Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190013/
https://www.ncbi.nlm.nih.gov/pubmed/25328697
http://dx.doi.org/10.1155/2014/267594
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author Berry, Cassandra M.
Penhale, William J.
Sangster, Mark Y.
author_facet Berry, Cassandra M.
Penhale, William J.
Sangster, Mark Y.
author_sort Berry, Cassandra M.
collection PubMed
description Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. Here, we review passive broad-spectrum influenza prophylaxis options with a focus on harnessing natural host defenses, including interferons and antibodies.
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spelling pubmed-41900132014-10-19 Passive Broad-Spectrum Influenza Immunoprophylaxis Berry, Cassandra M. Penhale, William J. Sangster, Mark Y. Influenza Res Treat Review Article Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. Here, we review passive broad-spectrum influenza prophylaxis options with a focus on harnessing natural host defenses, including interferons and antibodies. Hindawi Publishing Corporation 2014 2014-09-22 /pmc/articles/PMC4190013/ /pubmed/25328697 http://dx.doi.org/10.1155/2014/267594 Text en Copyright © 2014 Cassandra M. Berry et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Berry, Cassandra M.
Penhale, William J.
Sangster, Mark Y.
Passive Broad-Spectrum Influenza Immunoprophylaxis
title Passive Broad-Spectrum Influenza Immunoprophylaxis
title_full Passive Broad-Spectrum Influenza Immunoprophylaxis
title_fullStr Passive Broad-Spectrum Influenza Immunoprophylaxis
title_full_unstemmed Passive Broad-Spectrum Influenza Immunoprophylaxis
title_short Passive Broad-Spectrum Influenza Immunoprophylaxis
title_sort passive broad-spectrum influenza immunoprophylaxis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190013/
https://www.ncbi.nlm.nih.gov/pubmed/25328697
http://dx.doi.org/10.1155/2014/267594
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