The Effect of Morphine on Regional Cerebral Blood Flow Measured by (99m)Tc-ECD SPECT in Dogs

To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with (99m)Tc-Ethylcysteinate Dimer single photon emission computed tomography i...

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Detalles Bibliográficos
Autores principales: Adriaens, Antita, Peremans, Kathelijne, Waelbers, Tim, Vandermeulen, Eva, Croubels, Siska, Duchateau, Luc, Dobbeleir, André, Audenaert, Kurt, Eersels, Jos, Vermeire, Simon, De Spiegeleer, Bart, Polis, Ingeborgh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190363/
https://www.ncbi.nlm.nih.gov/pubmed/25295733
http://dx.doi.org/10.1371/journal.pone.0109680
Descripción
Sumario:To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with (99m)Tc-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.

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