Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice

The recently discovered mammalian enzyme cyclic GMP-AMP synthase produces cyclic GMP-AMP (cGAMP) after being activated by pathogen-derived cytosolic double stranded DNA. The product can stimulate STING-dependent interferon type I signaling. Here, we explore the efficacy of cGAMP as a mucosal adjuvan...

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Detalles Bibliográficos
Autores principales: Škrnjug, Ivana, Guzmán, Carlos Alberto, Ruecker, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190368/
https://www.ncbi.nlm.nih.gov/pubmed/25295996
http://dx.doi.org/10.1371/journal.pone.0110150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190368/
https://www.ncbi.nlm.nih.gov/pubmed/25295996
http://dx.doi.org/10.1371/journal.pone.0110150

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