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Cancer immunotherapy in clinical practice—the past, present, and future
Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immuno...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sun Yat-sen University Cancer Center
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190434/ https://www.ncbi.nlm.nih.gov/pubmed/25189717 http://dx.doi.org/10.5732/cjc.014.10123 |
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author | Goel, Gaurav Sun, Weijing |
author_facet | Goel, Gaurav Sun, Weijing |
author_sort | Goel, Gaurav |
collection | PubMed |
description | Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immunosuppressive microenvironment in the development of tumors has been established. The success of checkpoint-inhibiting antibodies and cancer vaccines has marked the beginning of a new era in cancer treatment. This review highlights the clinically relevant principles of cancer immunology and various immunotherapeutic approaches that have either already entered mainstream oncologic practice or are currently in the process of being evaluated in clinical trials. Furthermore, the current barriers to the development of effective immunotherapies and the potential strategies of overcoming them are also discussed. |
format | Online Article Text |
id | pubmed-4190434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-41904342014-10-15 Cancer immunotherapy in clinical practice—the past, present, and future Goel, Gaurav Sun, Weijing Chin J Cancer Review Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immunosuppressive microenvironment in the development of tumors has been established. The success of checkpoint-inhibiting antibodies and cancer vaccines has marked the beginning of a new era in cancer treatment. This review highlights the clinically relevant principles of cancer immunology and various immunotherapeutic approaches that have either already entered mainstream oncologic practice or are currently in the process of being evaluated in clinical trials. Furthermore, the current barriers to the development of effective immunotherapies and the potential strategies of overcoming them are also discussed. Sun Yat-sen University Cancer Center 2014-09 /pmc/articles/PMC4190434/ /pubmed/25189717 http://dx.doi.org/10.5732/cjc.014.10123 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Review Goel, Gaurav Sun, Weijing Cancer immunotherapy in clinical practice—the past, present, and future |
title | Cancer immunotherapy in clinical practice—the past, present, and future |
title_full | Cancer immunotherapy in clinical practice—the past, present, and future |
title_fullStr | Cancer immunotherapy in clinical practice—the past, present, and future |
title_full_unstemmed | Cancer immunotherapy in clinical practice—the past, present, and future |
title_short | Cancer immunotherapy in clinical practice—the past, present, and future |
title_sort | cancer immunotherapy in clinical practice—the past, present, and future |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190434/ https://www.ncbi.nlm.nih.gov/pubmed/25189717 http://dx.doi.org/10.5732/cjc.014.10123 |
work_keys_str_mv | AT goelgaurav cancerimmunotherapyinclinicalpracticethepastpresentandfuture AT sunweijing cancerimmunotherapyinclinicalpracticethepastpresentandfuture |