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Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain’s exceptional capacity for sequence variation

BACKGROUND: Variable loops 1 and 2 (V1V2) of the HIV-1 envelope glycoprotein gp120 perform two key functions: ensuring envelope trimer entry competence and shielding against neutralizing antibodies. While preserving entry functionality would suggest a high need for V1V2 sequence optimization and con...

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Detalles Bibliográficos
Autores principales:	Brandenberg, Oliver F, Rusert, Peter, Magnus, Carsten, Weber, Jacqueline, Böni, Jürg, Günthard, Huldrych F, Regoes, Roland R, Trkola, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190450/ https://www.ncbi.nlm.nih.gov/pubmed/25287422 http://dx.doi.org/10.1186/s12977-014-0075-y

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