Cargando…
Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population
BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator-1α (PPARGC1A/ PGC-1α) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The activity of PGC-1α or genetic variations in the gene encoding the enzyme may contribute to individual v...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190481/ https://www.ncbi.nlm.nih.gov/pubmed/25302081 http://dx.doi.org/10.1186/1758-5996-6-107 |
_version_ | 1782338520748130304 |
---|---|
author | Wu, Hui-Hui Liu, Nai-Jia Yang, Zhen Tao, Xiao-Ming Du, Yan-Ping Wang, Xuan-Chun Lu, Bin Zhang, Zhao-Yun Hu, Ren-Ming Wen, Jie |
author_facet | Wu, Hui-Hui Liu, Nai-Jia Yang, Zhen Tao, Xiao-Ming Du, Yan-Ping Wang, Xuan-Chun Lu, Bin Zhang, Zhao-Yun Hu, Ren-Ming Wen, Jie |
author_sort | Wu, Hui-Hui |
collection | PubMed |
description | BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator-1α (PPARGC1A/ PGC-1α) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The activity of PGC-1α or genetic variations in the gene encoding the enzyme may contribute to individual variations in mitochondrial function and insulin resistance or diabetes. The objective of this study was to assess the extent to which PPARGC1A (rs8192678) and serum uric acid (UA) and its interaction impact on T2DM susceptibility in Chinese Han population. METHOD: We conducted a study in a cohort that included 1166 T2DM patients and 1135 controls, and was genotyped for the presence of the PPARGC1A rs8192678 polymorphisms. Genotyping was performed by iPLEX technology. The association between rs8192678 or UA and T2DM was assessed by univariate and multivariate logistic regression (MLR) analysis controlling for confounders. The interaction between rs8192678 and UA for T2DM susceptibility was also assessed by MLR analysis. RESULTS: The generalized linear regression analysis failed to show an association between the PPARGC1A rs8192678 polymorphisms and T2DM. Interestingly, the present study provided data suggesting that the minor A-allele of PPARGC1A (rs8192678) had a protective effect against T2DM in subjects with higher level of UA (OR(int) =1.50 95% CI: 1.06-2.12 for allele and P = 0.02, OR(int) =1.63 95% CI: 1.17-2.26 for genotype and P = 0.004). CONCLUSION: The combination of higher level of UA and PPARGC1A (rs8192678) was an independent predictor for T2DM. |
format | Online Article Text |
id | pubmed-4190481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41904812014-10-10 Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population Wu, Hui-Hui Liu, Nai-Jia Yang, Zhen Tao, Xiao-Ming Du, Yan-Ping Wang, Xuan-Chun Lu, Bin Zhang, Zhao-Yun Hu, Ren-Ming Wen, Jie Diabetol Metab Syndr Research BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator-1α (PPARGC1A/ PGC-1α) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The activity of PGC-1α or genetic variations in the gene encoding the enzyme may contribute to individual variations in mitochondrial function and insulin resistance or diabetes. The objective of this study was to assess the extent to which PPARGC1A (rs8192678) and serum uric acid (UA) and its interaction impact on T2DM susceptibility in Chinese Han population. METHOD: We conducted a study in a cohort that included 1166 T2DM patients and 1135 controls, and was genotyped for the presence of the PPARGC1A rs8192678 polymorphisms. Genotyping was performed by iPLEX technology. The association between rs8192678 or UA and T2DM was assessed by univariate and multivariate logistic regression (MLR) analysis controlling for confounders. The interaction between rs8192678 and UA for T2DM susceptibility was also assessed by MLR analysis. RESULTS: The generalized linear regression analysis failed to show an association between the PPARGC1A rs8192678 polymorphisms and T2DM. Interestingly, the present study provided data suggesting that the minor A-allele of PPARGC1A (rs8192678) had a protective effect against T2DM in subjects with higher level of UA (OR(int) =1.50 95% CI: 1.06-2.12 for allele and P = 0.02, OR(int) =1.63 95% CI: 1.17-2.26 for genotype and P = 0.004). CONCLUSION: The combination of higher level of UA and PPARGC1A (rs8192678) was an independent predictor for T2DM. BioMed Central 2014-10-01 /pmc/articles/PMC4190481/ /pubmed/25302081 http://dx.doi.org/10.1186/1758-5996-6-107 Text en © Wu et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Wu, Hui-Hui Liu, Nai-Jia Yang, Zhen Tao, Xiao-Ming Du, Yan-Ping Wang, Xuan-Chun Lu, Bin Zhang, Zhao-Yun Hu, Ren-Ming Wen, Jie Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population |
title | Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population |
title_full | Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population |
title_fullStr | Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population |
title_full_unstemmed | Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population |
title_short | Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population |
title_sort | association and interaction analysis of ppargc1a and serum uric acid on type 2 diabetes mellitus in chinese han population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190481/ https://www.ncbi.nlm.nih.gov/pubmed/25302081 http://dx.doi.org/10.1186/1758-5996-6-107 |
work_keys_str_mv | AT wuhuihui associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT liunaijia associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT yangzhen associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT taoxiaoming associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT duyanping associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT wangxuanchun associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT lubin associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT zhangzhaoyun associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT hurenming associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation AT wenjie associationandinteractionanalysisofppargc1aandserumuricacidontype2diabetesmellitusinchinesehanpopulation |