Temperature Dependence of the Complexation Mechanism of Celecoxib and Hydroxyl-β-cyclodextrin in Aqueous Solution

Hydroxypropyl-β-cyclodextrin (HP-β-CD) is commonly used as a complexation reagent to solubilize compounds with poor aqueous solubility to improve in vivo dosing. However, the degree of solubility enhancement was often limited by the formation of only a 1:1 complex and a low complexation constant (K)...

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Detalles Bibliográficos
Autores principales: Chiang, Po-Chiang, Shi, Yue, Cui, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190530/
https://www.ncbi.nlm.nih.gov/pubmed/25123365
http://dx.doi.org/10.3390/pharmaceutics6030467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190530/
https://www.ncbi.nlm.nih.gov/pubmed/25123365
http://dx.doi.org/10.3390/pharmaceutics6030467

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