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Variant adiponutrin confers genetic protection against cholestatic itch

Lysophosphatidic acid (LPA) mediates cholestatic pruritus. Recently the enzyme PNPLA3, expressed in liver and skin, was demonstrated to metabolise LPA. Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in genome-...

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Detalles Bibliográficos
Autores principales:	Krawczyk, Marcin, Milkiewicz, Malgorzata, Marschall, Hanns-Ulrich, Bartz, Clemens, Grünhage, Frank, Wunsch, Ewa, Milkiewicz, Piotr, Lammert, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190538/ https://www.ncbi.nlm.nih.gov/pubmed/25297933 http://dx.doi.org/10.1038/srep06374

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