Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma

Cancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more...

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Autores principales: De Veirman, Kim, Rao, Luigia, De Bruyne, Elke, Menu, Eline, Van Valckenborgh, Els, Van Riet, Ivan, Frassanito, Maria Antonia, Di Marzo, Lucia, Vacca, Angelo, Vanderkerken, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190545/
https://www.ncbi.nlm.nih.gov/pubmed/24978438
http://dx.doi.org/10.3390/cancers6031363
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author De Veirman, Kim
Rao, Luigia
De Bruyne, Elke
Menu, Eline
Van Valckenborgh, Els
Van Riet, Ivan
Frassanito, Maria Antonia
Di Marzo, Lucia
Vacca, Angelo
Vanderkerken, Karin
author_facet De Veirman, Kim
Rao, Luigia
De Bruyne, Elke
Menu, Eline
Van Valckenborgh, Els
Van Riet, Ivan
Frassanito, Maria Antonia
Di Marzo, Lucia
Vacca, Angelo
Vanderkerken, Karin
author_sort De Veirman, Kim
collection PubMed
description Cancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more supportive microenvironment. The aim of the current review is to summarize the origin and characteristics of CAFs, and to describe the role of CAFs in tumor progression and metastasis. Furthermore, we focus on the presence of CAFs in hypoxic conditions in relation to multiple myeloma disease.
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spelling pubmed-41905452014-10-09 Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma De Veirman, Kim Rao, Luigia De Bruyne, Elke Menu, Eline Van Valckenborgh, Els Van Riet, Ivan Frassanito, Maria Antonia Di Marzo, Lucia Vacca, Angelo Vanderkerken, Karin Cancers (Basel) Review Cancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more supportive microenvironment. The aim of the current review is to summarize the origin and characteristics of CAFs, and to describe the role of CAFs in tumor progression and metastasis. Furthermore, we focus on the presence of CAFs in hypoxic conditions in relation to multiple myeloma disease. MDPI 2014-06-27 /pmc/articles/PMC4190545/ /pubmed/24978438 http://dx.doi.org/10.3390/cancers6031363 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
De Veirman, Kim
Rao, Luigia
De Bruyne, Elke
Menu, Eline
Van Valckenborgh, Els
Van Riet, Ivan
Frassanito, Maria Antonia
Di Marzo, Lucia
Vacca, Angelo
Vanderkerken, Karin
Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
title Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
title_full Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
title_fullStr Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
title_full_unstemmed Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
title_short Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
title_sort cancer associated fibroblasts and tumor growth: focus on multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190545/
https://www.ncbi.nlm.nih.gov/pubmed/24978438
http://dx.doi.org/10.3390/cancers6031363
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