Cargando…

Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral r...

Descripción completa

Detalles Bibliográficos
Autores principales: D’Souza, Gypsyamber, Kluz, Nicole, Wentz, Alicia, Youngfellow, Renee M., Griffioen, Anne, Stammer, Emily, Guo, Yingshi, Xiao, Weihong, Gillison, Maura L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190562/
https://www.ncbi.nlm.nih.gov/pubmed/25256827
http://dx.doi.org/10.3390/cancers6031691
_version_ 1782338537595600896
author D’Souza, Gypsyamber
Kluz, Nicole
Wentz, Alicia
Youngfellow, Renee M.
Griffioen, Anne
Stammer, Emily
Guo, Yingshi
Xiao, Weihong
Gillison, Maura L.
author_facet D’Souza, Gypsyamber
Kluz, Nicole
Wentz, Alicia
Youngfellow, Renee M.
Griffioen, Anne
Stammer, Emily
Guo, Yingshi
Xiao, Weihong
Gillison, Maura L.
author_sort D’Souza, Gypsyamber
collection PubMed
description Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man.
format Online
Article
Text
id pubmed-4190562
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-41905622014-10-09 Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults D’Souza, Gypsyamber Kluz, Nicole Wentz, Alicia Youngfellow, Renee M. Griffioen, Anne Stammer, Emily Guo, Yingshi Xiao, Weihong Gillison, Maura L. Cancers (Basel) Article Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man. MDPI 2014-08-14 /pmc/articles/PMC4190562/ /pubmed/25256827 http://dx.doi.org/10.3390/cancers6031691 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
D’Souza, Gypsyamber
Kluz, Nicole
Wentz, Alicia
Youngfellow, Renee M.
Griffioen, Anne
Stammer, Emily
Guo, Yingshi
Xiao, Weihong
Gillison, Maura L.
Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
title Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
title_full Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
title_fullStr Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
title_full_unstemmed Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
title_short Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
title_sort oral human papillomavirus (hpv) infection among unvaccinated high-risk young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190562/
https://www.ncbi.nlm.nih.gov/pubmed/25256827
http://dx.doi.org/10.3390/cancers6031691
work_keys_str_mv AT dsouzagypsyamber oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT kluznicole oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT wentzalicia oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT youngfellowreneem oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT griffioenanne oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT stammeremily oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT guoyingshi oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT xiaoweihong oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults
AT gillisonmaural oralhumanpapillomavirushpvinfectionamongunvaccinatedhighriskyoungadults