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Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral r...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190562/ https://www.ncbi.nlm.nih.gov/pubmed/25256827 http://dx.doi.org/10.3390/cancers6031691 |
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author | D’Souza, Gypsyamber Kluz, Nicole Wentz, Alicia Youngfellow, Renee M. Griffioen, Anne Stammer, Emily Guo, Yingshi Xiao, Weihong Gillison, Maura L. |
author_facet | D’Souza, Gypsyamber Kluz, Nicole Wentz, Alicia Youngfellow, Renee M. Griffioen, Anne Stammer, Emily Guo, Yingshi Xiao, Weihong Gillison, Maura L. |
author_sort | D’Souza, Gypsyamber |
collection | PubMed |
description | Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man. |
format | Online Article Text |
id | pubmed-4190562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41905622014-10-09 Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults D’Souza, Gypsyamber Kluz, Nicole Wentz, Alicia Youngfellow, Renee M. Griffioen, Anne Stammer, Emily Guo, Yingshi Xiao, Weihong Gillison, Maura L. Cancers (Basel) Article Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man. MDPI 2014-08-14 /pmc/articles/PMC4190562/ /pubmed/25256827 http://dx.doi.org/10.3390/cancers6031691 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article D’Souza, Gypsyamber Kluz, Nicole Wentz, Alicia Youngfellow, Renee M. Griffioen, Anne Stammer, Emily Guo, Yingshi Xiao, Weihong Gillison, Maura L. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults |
title | Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults |
title_full | Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults |
title_fullStr | Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults |
title_full_unstemmed | Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults |
title_short | Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults |
title_sort | oral human papillomavirus (hpv) infection among unvaccinated high-risk young adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190562/ https://www.ncbi.nlm.nih.gov/pubmed/25256827 http://dx.doi.org/10.3390/cancers6031691 |
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