A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

Streptococcus pneumoniae (the pneumococcus) is the world’s foremost bacterial pathogen in both morbidity and mortality. Switching between phenotypic forms (or ‘phases’) that favour asymptomatic carriage or invasive disease was first reported in 1933. Here, we show that the underlying mechanism for s...

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Detalles Bibliográficos
Autores principales: Manso, Ana Sousa, Chai, Melissa H., Atack, John M., Furi, Leonardo, De Ste Croix, Megan, Haigh, Richard, Trappetti, Claudia, Ogunniyi, Abiodun D., Shewell, Lucy K., Boitano, Matthew, Clark, Tyson A., Korlach, Jonas, Blades, Matthew, Mirkes, Evgeny, Gorban, Alexander N., Paton, James C., Jennings, Michael P., Oggioni, Marco R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190663/
https://www.ncbi.nlm.nih.gov/pubmed/25268848
http://dx.doi.org/10.1038/ncomms6055

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