Analysis of Parkinson's disease brain–derived DNA for alpha-synuclein coding somatic mutations

BACKGROUND: Although alpha-synuclein (SNCA) is crucial to the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB), mutations in the gene appear to be rare. We have recently hypothesized that somatic mutations in early development could contribute to PD. METHODS: Expandi...

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Detalles Bibliográficos
Autores principales: Proukakis, Christos, Shoaee, Maryiam, Morris, James, Brier, Timothy, Kara, Eleanna, Sheerin, Una-Marie, Charlesworth, Gavin, Tolosa, Eduardo, Houlden, Henry, Wood, Nicholas W, Schapira, Anthony H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190821/
https://www.ncbi.nlm.nih.gov/pubmed/24752924
http://dx.doi.org/10.1002/mds.25883

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