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Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆
Tumor models were simulated in purebred Beagles at the T(9-10) levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T(9-10) levels was observed, includ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190856/ https://www.ncbi.nlm.nih.gov/pubmed/25317124 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.35.002 |
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author | Xu, Wanlong Xilinbaoleri, Liu, Hao Wang, Ruozheng Bai, Jingping |
author_facet | Xu, Wanlong Xilinbaoleri, Liu, Hao Wang, Ruozheng Bai, Jingping |
author_sort | Xu, Wanlong |
collection | PubMed |
description | Tumor models were simulated in purebred Beagles at the T(9-10) levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T(9-10) levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy. |
format | Online Article Text |
id | pubmed-4190856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41908562014-10-14 Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ Xu, Wanlong Xilinbaoleri, Liu, Hao Wang, Ruozheng Bai, Jingping Neural Regen Res Spinal Cord Injury and Neural Regeneration Tumor models were simulated in purebred Beagles at the T(9-10) levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T(9-10) levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy. Medknow Publications & Media Pvt Ltd 2012-12-15 /pmc/articles/PMC4190856/ /pubmed/25317124 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.35.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Spinal Cord Injury and Neural Regeneration Xu, Wanlong Xilinbaoleri, Liu, Hao Wang, Ruozheng Bai, Jingping Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ |
title | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ |
title_full | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ |
title_fullStr | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ |
title_full_unstemmed | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ |
title_short | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ |
title_sort | spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy☆ |
topic | Spinal Cord Injury and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190856/ https://www.ncbi.nlm.nih.gov/pubmed/25317124 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.35.002 |
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