Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★

The present study monitored the effect of 2, 10, and 50 mg/L of Panax notoginseng saponin exposure following hypoxia-reoxygenation injury in fetal rat cortical neurons. Results showed that varying doses of Panax notoginseng saponin significantly enhanced the cell viability of neurons, reduced malond...

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Autores principales: Yan, Chen, Zhu, Jinqiang, Jia, Xiaoxu, Wang, Chao, Wang, Shaoxia, Kang, Liyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Traditional Chinese Medicine and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190942/
https://www.ncbi.nlm.nih.gov/pubmed/25317136
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.36.001
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author Yan, Chen
Zhu, Jinqiang
Jia, Xiaoxu
Wang, Chao
Wang, Shaoxia
Kang, Liyuan
author_facet Yan, Chen
Zhu, Jinqiang
Jia, Xiaoxu
Wang, Chao
Wang, Shaoxia
Kang, Liyuan
author_sort Yan, Chen
collection PubMed
description The present study monitored the effect of 2, 10, and 50 mg/L of Panax notoginseng saponin exposure following hypoxia-reoxygenation injury in fetal rat cortical neurons. Results showed that varying doses of Panax notoginseng saponin significantly enhanced the cell viability of neurons, reduced malondialdehyde content, increased superoxide dismutase activity, inhibited mRNA and protein expression of inducible and neuronal nitric oxide synthase, and decreased the release of nitric oxide in hypoxia/reoxygenation injured cells. In particular, 50 mg/L of Panax notoginseng saponin was the most effective dose. These findings suggest that Panax notoginseng saponin can attenuate neuronal oxidative stress injury caused by hypoxia/reoxygenation in a dose-dependent manner.
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spelling pubmed-41909422014-10-14 Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★ Yan, Chen Zhu, Jinqiang Jia, Xiaoxu Wang, Chao Wang, Shaoxia Kang, Liyuan Neural Regen Res Traditional Chinese Medicine and Neural Regeneration The present study monitored the effect of 2, 10, and 50 mg/L of Panax notoginseng saponin exposure following hypoxia-reoxygenation injury in fetal rat cortical neurons. Results showed that varying doses of Panax notoginseng saponin significantly enhanced the cell viability of neurons, reduced malondialdehyde content, increased superoxide dismutase activity, inhibited mRNA and protein expression of inducible and neuronal nitric oxide synthase, and decreased the release of nitric oxide in hypoxia/reoxygenation injured cells. In particular, 50 mg/L of Panax notoginseng saponin was the most effective dose. These findings suggest that Panax notoginseng saponin can attenuate neuronal oxidative stress injury caused by hypoxia/reoxygenation in a dose-dependent manner. Medknow Publications & Media Pvt Ltd 2012-12-25 /pmc/articles/PMC4190942/ /pubmed/25317136 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.36.001 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Traditional Chinese Medicine and Neural Regeneration
Yan, Chen
Zhu, Jinqiang
Jia, Xiaoxu
Wang, Chao
Wang, Shaoxia
Kang, Liyuan
Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
title Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
title_full Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
title_fullStr Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
title_full_unstemmed Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
title_short Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
title_sort panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
topic Traditional Chinese Medicine and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190942/
https://www.ncbi.nlm.nih.gov/pubmed/25317136
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.36.001
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