Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆

Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ische...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Gan, Weidong, An, Guoyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Traditional Chinese Medicine and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190946/
https://www.ncbi.nlm.nih.gov/pubmed/25317140
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.36.005
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author Zhang, Li
Gan, Weidong
An, Guoyao
author_facet Zhang, Li
Gan, Weidong
An, Guoyao
author_sort Zhang, Li
collection PubMed
description Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection.
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spelling pubmed-41909462014-10-14 Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆ Zhang, Li Gan, Weidong An, Guoyao Neural Regen Res Traditional Chinese Medicine and Neural Regeneration Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection. Medknow Publications & Media Pvt Ltd 2012-12-25 /pmc/articles/PMC4190946/ /pubmed/25317140 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.36.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Traditional Chinese Medicine and Neural Regeneration
Zhang, Li
Gan, Weidong
An, Guoyao
Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆
title Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆
title_full Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆
title_fullStr Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆
title_full_unstemmed Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆
title_short Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury☆
title_sort influence of tanshinone iia on heat shock protein 70, bcl-2 and bax expression in rats with spinal ischemia/reperfusion injury☆
topic Traditional Chinese Medicine and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190946/
https://www.ncbi.nlm.nih.gov/pubmed/25317140
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.36.005
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AT anguoyao influenceoftanshinoneiiaonheatshockprotein70bcl2andbaxexpressioninratswithspinalischemiareperfusioninjury

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