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Maternally transmitted mitochondrial DNA mutations can reduce lifespan

We recently showed that germline transmission of mitochondrial DNA mutations via the oocyte cause aggravation of aging phenotypes in prematurely aging mtDNA mutator (PolgA(mut/mut)) mice. We discovered that 32% of these mice also exhibit stochastic disturbances of brain development, when maternal mt...

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Detalles Bibliográficos
Autores principales:	Ross, Jaime M., Coppotelli, Giuseppe, Hoffer, Barry J., Olson, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190956/ https://www.ncbi.nlm.nih.gov/pubmed/25299268 http://dx.doi.org/10.1038/srep06569

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