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Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists

[Image: see text] The endotoxic portion of lipopolysaccharide (LPS), a glycophospholipid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)–myeloid differentiation factor 2 (MD-2) complex, which results in pro-inflammatory immune signaling. To unveil the structural requirements for...

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Detalles Bibliográficos
Autores principales:	Adanitsch, Florian, Ittig, Simon, Stöckl, Johannes, Oblak, Alja, Haegman, Mira, Jerala, Roman, Beyaert, Rudi, Kosma, Paul, Zamyatina, Alla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191062/ https://www.ncbi.nlm.nih.gov/pubmed/25252784 http://dx.doi.org/10.1021/jm500946r

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