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Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes
The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature lineage-committed one has been historically understood in terms of Waddington's landscape, consisting of hills and valleys. The smooth top and valley-strewn bottom of the hill represent their undifferentiat...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191102/ https://www.ncbi.nlm.nih.gov/pubmed/25165605 http://dx.doi.org/10.1098/rsif.2014.0706 |