Cargando…

Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK

Glucocorticoids (Gc) are potent anti-inflammatory agents with wide clinical application. We have previously shown that increased serum concentration significantly attenuates regulation of a simple Gc-responsive reporter. We now find that glucocorticoid receptor (GR) regulation of some endogenous tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Nan, Caratti, Giorgio, Ince, Louise M, Poolman, Toryn M, Trebble, Peter J, Holt, Cathy M, Ray, David W, Matthews, Laura C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191185/ https://www.ncbi.nlm.nih.gov/pubmed/25161081 http://dx.doi.org/10.1530/JOE-14-0456

Ejemplares similares

REVERBa couples the circadian clock to hepatic glucocorticoid action
por: Caratti, Giorgio, et al.
Publicado: (2018)

HNF4A modulates glucocorticoid action in the liver
por: Hunter, A. Louise, et al.
Publicado: (2022)

Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection
por: Caratti, G., et al.
Publicado: (2019)

The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer
por: Jangani, Maryam, et al.
Publicado: (2014)

A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response
por: Ptushkina, Marina, et al.
Publicado: (2017)

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production
por: Morgan, David J., et al.
Publicado: (2016)

Cell Cycle Phase Regulates Glucocorticoid Receptor Function
por: Matthews, Laura, et al.
Publicado: (2011)

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1
por: McCaffrey, James C., et al.
Publicado: (2017)

Pin1 promotes GR transactivation by enhancing recruitment to target genes
por: Poolman, Toryn M., et al.
Publicado: (2013)

Glucocorticoids Shape Macrophage Phenotype for Tissue Repair
por: Desgeorges, Thibaut, et al.
Publicado: (2019)

Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance
por: Caratti, Giorgio, et al.
Publicado: (2023)

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis
por: Koenen, Mascha, et al.
Publicado: (2018)

Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids
por: Caratti, Giorgio, et al.
Publicado: (2022)

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
por: Escoter-Torres, Laura, et al.
Publicado: (2019)

Protein Kinase C Epsilon Contributes to NADPH Oxidase Activation in a Pre-Eclampsia Lymphoblast Cell Model
por: Poolman, Toryn M., et al.
Publicado: (2013)

Teaching genomics to life science undergraduates using cloud computing platforms with open datasets
por: Poolman, Toryn M., et al.
Publicado: (2022)

A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells()
por: Mistry, Yogita, et al.
Publicado: (2013)

Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells
por: Ince, Louise M., et al.
Publicado: (2019)

Serum Fructosamine, Total Cholesterol, and High-Density Lipoprotein in Children with Asthma during Glucocorticoid Treatment
por: Schou, A. J., et al.
Publicado: (2011)

Glucocorticoid sensitivity in Behçet's disease
por: Quax, R A M, et al.
Publicado: (2012)

THE EFFECTS OF CHOLESTEROL DOSAGE, CORTISONE, AND DCA ON TOTAL SERUM CHOLESTEROL, LIPOPROTEINS, AND ATHEROSCLEROSIS IN THE RABBIT
por: Cook, Donald L., et al.
Publicado: (1952)

Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re‐sensitization by JNK inhibition
por: Nicholson, Lindsay, et al.
Publicado: (2015)

Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β
por: Shapira, Keren E., et al.
Publicado: (2014)

Serum cholesterol and cancer.
por: Law, M. R.
Publicado: (1992)

Sensitivity and resistance to glucocorticoids
por: Chrousos, George
Publicado: (2014)

Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle
por: Stifel, Ulrich, et al.
Publicado: (2021)

Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling
por: Murtagh, Janice, et al.
Publicado: (2004)

Dexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFβ and JNK/AP-1
por: Liu, Li, et al.
Publicado: (2017)

Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c‐Jun pathway
por: Peng, Puji, et al.
Publicado: (2020)

Variation in glucocorticoid sensitivity and the relation with obesity
por: Lengton, Robin, et al.
Publicado: (2021)

Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML
por: Malani, D, et al.
Publicado: (2017)

In vitro glucocorticoid sensitivity is associated with clinical glucocorticoid therapy outcome in rheumatoid arthritis
por: Quax, Rogier AM, et al.
Publicado: (2012)

Glucocorticoids Antagonize Ap-1 by Inhibiting the Activation/Phosphorylation of Jnk without Affecting Its Subcellular Distribution
por: González, María Victoria, et al.
Publicado: (2000)

Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells
por: Kay, Paul, et al.
Publicado: (2011)

Selection of glucocorticoid-sensitive patients in interstitial lung disease secondary to connective tissue diseases population by radiomics
por: Feng, Ding-Yun, et al.
Publicado: (2018)

Correction: Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells
por: Kay, Paul, et al.
Publicado: (2013)

Efficacy and safety of selective glucocorticoid receptor modulators in comparison to glucocorticoids in arthritis, a systematic review
por: Safy, M., et al.
Publicado: (2017)

What do patients want from their endoscopy experience? The importance of measuring and understanding patient attitudes to their care
por: Tierney, M, et al.
Publicado: (2016)

Correlations of MIF polymorphism and serum levels of MIF with glucocorticoid sensitivity of sudden sensorineural hearing loss
por: Zhu, Wen-Yan, et al.
Publicado: (2019)

Circadian clock function does not require the histone methyltransferase MLL3
por: Baxter, Matthew, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ha9p00s3dhslorq6uq7tq323c0