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Invincible DNA tethers: covalent DNA anchoring for enhanced temporal and force stability in magnetic tweezers experiments
Magnetic tweezers are a powerful single-molecule technique that allows real-time quantitative investigation of biomolecular processes under applied force. High pulling forces exceeding tens of picoNewtons may be required, e.g. to probe the force range of proteins that actively transcribe or package...
Autores principales: | Janissen, Richard, Berghuis, Bojk A., Dulin, David, Wink, Max, van Laar, Theo, Dekker, Nynke H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191378/ https://www.ncbi.nlm.nih.gov/pubmed/25140010 http://dx.doi.org/10.1093/nar/gku677 |
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