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The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor expressed in metazoan cells that is responsible for eliciting the production of type I interferons and pro-inflammatory cytokines upon detection of intracellular, non-self RNA. Structural studies of RIG-I have identified a nove...

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Detalles Bibliográficos
Autores principales:	Rawling, David C., Kohlway, Andrew S., Luo, Dahai, Ding, Steve C., Pyle, Anna Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191399/ https://www.ncbi.nlm.nih.gov/pubmed/25217590 http://dx.doi.org/10.1093/nar/gku817

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